A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) by Mahrokh Marzi, Mojtaba Farjam, Zahra Kazeminejad, Abolfazl Shiroudi, Amin Kouhpayeh, Elham Zarenezhad

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Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided cancer therapy by Ying Zhou, Chen Cheng, Qi Wang, Min Zheng, Pan Li, Yang Zhou, Yuting Cao, Li Wan, Xun Guo, Xiaohong Lin, Rui Tang, Hongye He, Nianhong Wu, Qiaoqi Chen, Yaqin Hu, Xialin Xiong, Faqi Li

“…Here, we describe a synergistic regimen combining HIFU facilitation with immunomodulation based on a novel oxygen-carrying biomimetic perfluorocarbon nanoparticle (M@P-SOP) to stimulate immunogenic cell death in tumor cells while alleviating immune suppression tumor microenvironment.Methods M@P-SOP was prepared by double emulsion and film extrusion method. …”
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Development and validation of a novel risk-predicted model for early sepsis-associated acute kidney injury in critically ill patients: a retrospective cohort study by Bo Li, Kun Zhang, Cong-Cong Zhao, Zi-Han Nan, Yan-Ling Yin, Li-Xia Liu, Zhen-Jie Hu

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Novel Insights into the Nobilamide Family from a Deep-Sea <i>Bacillus</i>: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria by Vincenza Casella, Gerardo Della Sala, Silvia Scarpato, Carmine Buonocore, Costanza Ragozzino, Pietro Tedesco, Daniela Coppola, Giovanni Andrea Vitale, Donatella de Pascale, Fortunato Palma Esposito

“…Particularly, 84 nobilamide congeners were identified in the bacterial exometabolome, 71 of them being novel metabolites. Among these, four major compounds were isolated, including the known TL-119 and nobilamide I, as well as the two new nobilamides T1 and S1. …”
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Perseguir el sueño o caer en lo que existe: la socialización del maestro novel entre el habitus y la investigaciónacción by José Juan Barba Martín, Gustavo González Calvo

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A novel intraoperative Esophagus-Sparing Anastomotic Narrowing Revision (ESANR) technique for patients who underwent esophagojejunostomy: three case reports and a review of the literature by Jian Zhou, Zhenhong Wang, Guobiao Chen, Yi Li, Min Cai, Fathima Shifly Pannikkodan, Xiangzhi Qin, Dan Bai, Zhenbing Lv, Lei Gong, Yunhong Tian

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The Reliability and Validity of a Novel Clinical Test for Assessing Shoulder Rotation ROM in Collegiate Baseball Players: Functional Assessment of System Tension of the Shoulder (FAST-SHDR) by Steven Dischiavi, Jesse Perry, Connor Burk, Jeremy Chiang, Chris Bleakley

“…Within and between group differences were based on t-tests (p<0.001), absolute differences and effect sizes (95% CIs). # Results The novel test (FAST-SHDR) had good to excellent reliability with ICCs ranging from 0.95 (0.89 to 0.98) to 0.96 (0.92-0.98). …”
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Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data by Nair, Bharath, Palomo, Ismael Rodríguez, Markussen, Bo, Wiuf, Carsten, Fiddyment, Sarah, Collins, Matthew James

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Anomaly Detection and Root Cause Analysis for Energy Consumption of Medium and Heavy Plate: A Novel Method Based on Bayesian Neural Network with Adam Variational Inference by Qiang Guo, Fenghe Li, Hengwen Liu, Jin Guo

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Introducing a Novel Clustering Method for Distribution Networks to Enhance Network Performance and Ensure Load Supply in the Event of Contingencies: A Fuzzy Function-Based Approach by Mohamad Reza Mohamadi, Mohammad Sadegh Ghazizadeh, Mohamad Abedini

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Effectiveness of a novel artificial intelligence-assisted colonoscopy system for adenoma detection: a prospective, propensity score-matched, non-randomized controlled study in Korea by Jung-Bin Park, Jung Ho Bae

“…We assessed the effectiveness of the novel CADe system, ENdoscopy as AI-powered Device (ENAD), in enhancing the adenoma detection rate (ADR) and other quality indicators in real-world clinical practice. …”
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Discovery of a Novel Insecticidal Peptide with a Cystine-Stabilized α-Helix/α-Helix Motif from the Venom of Scorpion <i>Liocheles australasiae</i> by Masahiro Miyashita, Naoya Mitani, Fuki Iwamoto, Mitsuki Hirota, Yoshiaki Nakagawa

“…In this study, with the aim of discovering novel insecticidal peptides, we synthesized five peptides, which were predicted to adopt a CSαα motif, identified from the venom of the scorpion <i>Liocheles australasiae</i>, and measured their insecticidal activity. …”
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Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies by Dong-Sup Lee, Mi-Ju Park, Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Byung-Jin Jung, Yun-Kyoung Hong, Keunhee Oh

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Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids by Margherita Maioli, Valentina Basoli, Sara Santaniello, Sara Cruciani, Alessandro Palmerio Delitala, Roberto Pinna, Egle Milia, Regina Grillari-Voglauer, Vania Fontani, Salvatore Rinaldi, Roberta Muggironi, Gianfranco Pigliaru, Carlo Ventura

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Neutrophil-to-lymphocyte ratio as a novel predictor of sarcopenia in maintenance hemodialysis patients: a cross-sectional study exploring associations across body composition categories by Yogesh M., Parth Anilbhai Parmar, Soumya Sharma, Jay Pareshbhai Kakadiya, Dhruv Lakkad

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Thioxopyrimidine in Heterocyclic Synthesis III: Synthesis and Properties of Some Novel Heterocyclic Chalcone Derivatives Containing a Thieno[2,3-d]pyrimidine-Based Chromophore by Yuh Wen Ho, Wei Hua Yao

“…On the other hand, a series of novel 3-aryl-1-[4-methyl-2-phenyl-5-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-6-yl]prop-2-en-1-one chalcone dyes 6a—n were obtained by the condensation reaction of 1-[4-methyl-2-phenyl-5(1H-pyrrol-1-yl)thieno[2,3-d]-pyrimidin-6-yl]ethanone 4 with appropriate aldehydes. …”
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Two Novel Compounds Isolated from the Marine Fungal Symbiont of Aspergillus unguis Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells: In vitro Study by Bashari MH, Agung MUK, Ariyanto EF, Al Muqarrabun LMR, Salsabila S, Chahyadi A, Rosandy AR, Afifah E, Afni M, Atmaja HE, Putri T, Utami F, Subhan B, Syafrizayanti, Andriani Y, Elfahmi

“…Not only viability, apoptosis, and cell cycle analyses were conducted, but also the mRNA expression of MCL1, BCL2L1, AKT1 and CDK2 were evaluated.Results: The extract showed cytotoxic activity in breast cancer cells. Two novel compounds were successfully isolated and identified, ie, Unguisol A (15.1 mg) and Unguisol B (97.9 mg). …”
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A pressure sensor made of laser-induced graphene@carbon ink in a waste sponge substrate using novel and simple fabricaing process for health monitoring by Aoxun Liang, Weijie Liu, Yuanrui Cui, Peihua Zhang, Xinkun Chen, Junlong Zhai, Wenhao Dong, Xueye Chen

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Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks by Yufei Wang, Siyi Xu, Xia Chen, Yunlong Dou, Xingzhu Yang, Zenglei Hu, Shuang Wu, Xiaoquan Wang, Jiao Hu, Xiufan Liu

“…The novel duck reovirus (NDRV) disease causes high economic losses, resulting in substantial economic losses in waterfowl industry. …”
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Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents by Aouad Mohamed Reda, Messali Mouslim, Rezki Nadjet, Ali Adeeb Al-Sheikh, Lesimple Alain

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