Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma: Clinical Application to Therapeutic Drug Monitoring by Naser F. Al-Tannak, Ahmed Hemdan, Maya S. Eissa

“…A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal standard (IS) where the extraction process was conducted using automated SPE. …”
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A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disease by Shankar J. Chinta, Subramanian Rajagopalan, Abirami Ganesan, Julie K. Andersen

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A novel machine learning-based immune prognostic signature for improving clinical outcomes and guiding therapy in colorectal cancer: an integrated bioinformatics and experimental study by Yuanchun Zhao, Dexu Xun, Jiajia Chen, Xin Qi

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Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti‐PD‐1 therapy by Sung‐Woo Lee, Young Ju Kim, Saei Jeong, Kyung Na Rho, Jeong Eun Noh, Hee‐Ok Kim, Hyun‐Ju Cho, Yoo Duk Choi, Deok Hwan Yang, Eu Chang Hwang, Woo Kyun Bae, Sook Jung Yun, Ju Sik Yun, Cheol‐Kyu Park, In‐Jae Oh, Jae‐Ho Cho

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Removal of Malachite Green Dye from Aqueous Solution by a Novel Activated Carbon Prepared from Baobab Seeds Using Chemical Activation Method by Samah Daffalla

“…It was demonstrated that activating baobab with sulfuric acid can form a novel activated carbon that can quickly remove MG from aqueous solutions. …”
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Pyrogallol acts as a novel anticancer factor to enhance the sensitivity to cisplatin in ovarian cancer cells through inducing miR-15a upregulation by Azin Shirani, Razieh Mirabbasi, Leila Shabani, Somayeh Reiisi

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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…In healthy tissues, binding to EpCAM and CD3 is greatly reduced by a novel, dual CAB selection, where each binding domain is independently blocked by the presence of physiological chemicals known as Protein-associated Chemical Switches (PaCS). …”
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Effects of position of semi-circular body on melting of a novel B4C/RT44HC PCM nanocomposite in a closed space by Ezgi Gurgenc, Muhammed Gur, Hakan Cosanay, Turan Gurgenc, Hakan F. Oztop

“…This study focuses on optimizing the thermal performance of a novel Boron Carbide (B4C) enhanced RT44HC phase change material (PCM) nanocomposite by analyzing the effects of different semi-circular partition placements within a closed cavity. …”
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Characteristics of compound heat and drought events during the spring maize growing season in Northeast China Based on a novel daily-scale analysis framework by Jianhua Yang, Jianjun Wu, Lei Zhou, Hongkui Zhou, Zhenqing Zhang, Ruilin Zhang

“…This research advances understanding of CHDEs in spring maize and offers a novel daily-scale framework for crop CHDE analysis.…”
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A novel activated carbon material from peanut shells for the removal of methyl orange and methylene blue dyes from wastewater: kinetics, isotherms and mechanism by Oluwagbemi Aladeokin, Ashleigh Fletcher

“…This study investigated the removal of methyl orange (MO) and methylene blue (MB) dyes from an aqueous phase using a novel activated carbon material derived from peanut shells. …”
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Comprehensive study on cooling effectiveness and thermoelectric conversion of a novel helium/hydrogen-based closed Brayton cooling system for a hydrogen aero-engine by Qiurui Xin, Xiaohui Bai, Helong Jin, Chengao Duan, Yuxi Li, Cunliang Liu

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The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor by Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington

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Subjective cognition in schizophrenia and bipolar disorder: Investigation of group differences and associations with objective cognition and clinical characteristics using a novel measure of subjective cognition by Kristoffer Grimstad, Håkon Sørensen, Anja Vaskinn, Christine Mohn, Stine Holmstul Olsen, Ole A. Andreassen, Trine Vik Lagerberg, Ingrid Melle, Merete Glenne Øie, Torill Ueland, Beathe Haatveit

“…Here we investigated subjective cognition in SZ and BD compared to healthy controls (HC).Subjective and objective cognition were assessed in 91 SZ participants, 55 BD participants and 55 HC, applying a novel measure of subjective cognition, the self-assessed cognitive complaints scale (SACCS) and a clinically relevant neuropsychological test battery. …”
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Ultrasonic Irradiation: Synthesis, Characterization, and Preliminary Antimicrobial Activity of Novel Series of 4,6-Disubstituted-1,3,5-triazine Containing Hydrazone Derivatives by Hessa H. Al-Rasheed, Monirah Al Alshaikh, Jamal M. Khaled, Naiyf S. Alharbi, Ayman El-Faham

“…Novel series of 4,6-disubstituted-1,3,5-triazines containing hydrazone derivatives were synthesized employing ultrasonic irradiation and conventional heating. …”
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Application of two novel anionic peroxidases from Raphanus sativus L. var niger roots in labeling antibodies and developing an enzyme-linked immunosorbent assay by Hooman Askari, Ali Nabati, Aliasghar Rahimian, Mahdi Aminian

“…Here, we evaluated the applicability of these two novel peroxidases as alternatives to traditional horseradish peroxidase (HRP). …”
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Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells by Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang

“…This study discovered a novel class of compound that targets MDM2-MDM4 ubiquitin E3 ligase activity for apoptosis induction in p53-mutant cancer cells.…”
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Report of a Novel Mutation in MLH1 Gene in a Hispanic Family from Puerto Rico Fulfilling Classic Amsterdam Criteria for Lynch Syndrome by Juan M. Marqués-Lespier, Yaritza Diaz-Algorri, Maria Gonzalez-Pons, Marcia Cruz-Correa

“…In this paper we report a novel mutation in the hMLH1 gene in a Puerto Rican Hispanic family with Lynch syndrome recruited through the Puerto Rico Familial Colorectal Cancer Registry (PURIFICAR). …”
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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

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A novel broad-spectrum bacteriophage cocktail against methicillin-resistant Staphylococcus aureus: Isolation, characterization, and therapeutic potential in a mastitis mouse model. by Maryam Banar, Haniyeh Kamyab, Narges Torkashvand, Taghi Zahraei Salehi, Zargham Sepehrizadeh, Ahmad Reza Shahverdi, Mohammad Reza Pourmand, Mohammad Hossein Yazdi

“…This study evaluated the therapeutic potency of a novel bacteriophage cocktail against MRSA mastitis. …”
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Understanding the Spectrum of Mild Clinical Outcomes and Novel Findings in Arterial Tortuosity Syndrome Among Qatari Patients: Implications of SLC2A10 Mutation by Muhammed Riyas K. Rahmath, Haytham Ibrahim, Muhammad Faiyaz-Ul-Haque, Zafar Nawaz, Ahmad Zitoun, Ahmed Hussein, Ahmed Sadek, Ayman El-Menyar, Reema Kamal, Hassan Al-Thani, Gulab Sher

“…<b>Results</b>: The study revealed that the NM_030777.4(SLC2A10):c.243C>G (p.Ser81Arg) mutation in SLC2A10 leads to mild outcomes of no mortality and less morbidity. Novel features such as a flat philtrum, bulbous noses, bilateral nasolacrimal duct obstruction, allergic conjunctivitis, latent nystagmus, café au lait spots, eczema, dermatitis, allergic reactions, bilateral temporomandibular joint cysts, bilateral syndactyly (toes), parapelvic cysts, kidney malrotation, vesicoureteral reflux, and nephrolithiasis were identified in our cohort. …”
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