A novel ARCN1 splice-site variant in a Chinese girl with central precocious puberty, intrauterine growth restriction, microcephaly, and microretrognathia by Guoying Chang, Fan Yang, Lingwen Ying, Qianwen Zhang, Biyun Feng, Yao Chen, Yu Ding, Tingting Yu, Ruen Yao, Kana Lin, Juan Li, Xiumin Wang

“…Whole-exome sequencing identified a novel splice-site variant, NM_001655.5: c.1241 + 1G > A, in the ARCN1 gene. …”
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A Novel Approach for Rehabilitation of a Subtotal Maxillectomy Patient with Immediately Loaded Basal Implant-Supported Prosthesis: 4 Years Follow-Up by Motaz Osman, Abdelnasir G. Ahmad, Fadia Awadalkreem

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Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

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Novel NOTCH3 mutation c.1564 T > A (p.Cys522Ser) presenting with early-onset Parkinsonism and white matter lesions by Nicola Rifino, Silvia Baratta, Esteban Zacarias, Isabella Canavero, Benedetta Storti, Mario Stanziano, Emanuela Maderna, Gianluca Marucci, Franco Taroni, Anna Bersano

“…This report presents a novel NOTCH3 c.1564 T > A (p.Cys522Ser) mutation associated with early-onset parkinsonism and significant white matter lesions. …”
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Effect of novel accelerated intermittent theta burst stimulation on suicidal ideation in adolescent patients with major depressive episode: a randomised clinical trial by Dong Huang, Shuming Zhong, Xiaodong Song, Rongxu Zhang, Shunkai Lai, Yanbin Jia

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A Novel Gel Polymer Electrolyte by Thiol-Ene Click Reaction Derived from CO2-Based Polycarbonate for Lithium-Ion Batteries by Wenhan Luo, Kuirong Deng, Shuanjin Wang, Shan Ren, Dongmei Han, Yufei Wang, Min Xiao, Yuezhong Meng

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A novel mathematical model with an LCA-based solution method to minimize earliness-tardiness costs on a single machine by considering batch delivery by Zahra Pourali, Bohlool Ebrahimi

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Identification of a putative novel polycyclic aromatic hydrocarbon-biodegrading gene cluster in a marine Roseobacteraceae bacterium Sagittula sp. MA-2 by Mayuko Abe, Miharu Sakai, Robert A. Kanaly, Jiro F. Mori

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A Recurrent Nonsense Mutation in NECTIN4 Underlying Ectodermal Dysplasia-Syndactyly Syndrome with a Novel Phenotype in a Consanguineous Kashmiri Family by Ghazanfar Ali, Sadia Sadia, Syeda Ain-ul- Batool, Zahid Azeem, Naheed Bashir Awan, Syed Akif Raza Kazmi, Zia- Ur- Rehman, Zeeshan Anjum, Fazal- Ur- Rehman, Abdul Wali, Kafaitullah Khan, Nasib Zaman, Muhammad Ayub, Muhammad Sajid, Noor Hassan

“…In addition to the previously reported clinical phenotype, an upper lip cleft was found in one of the affected members as a novel phenotype that is not reported by previous studies in EDSS1 patients. …”
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A Novel Tool for High-Throughput Screening of Granulocyte-Specific Antibodies Using the Automated Flow Cytometric Granulocyte Immunofluorescence Test (Flow-GIFT) by Xuan Duc Nguyen, Thomas Dengler, Monika Schulz-Linkholt, Harald Klüter

“…The flow cytometric granulocyte immunofluorescence test (Flow-GIFT) has been introduced for routine use when investigating patients and healthy blood donors. Here we describe a novel tool in the automation of the Flow-GIFT that enables a rapid screening of blood donations. …”
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Novel Catalyst-Free Synthesis of Some 3‑Alkylaminoquinoxaline-2(1H)‑thiones and 3‑Alkyloxyquinoxaline-2(1H)‑thiones in Ethanol by Samir M. El Rayes, Ibrahim A. I. Ali, Walid Fathalla, Mohamed A. Ghanem, Afaf H. El-Sagheer

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Novel insight into the microstructure evolution and defect formation of nano-polycrystalline CoCrFeNi HEA during vacuum hot-pressing sintering by Bowen Dong, Liwei Chen, Zhenpeng Wu, Jinchuan Jie

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BLSENet: A Novel Lightweight Bilinear Convolutional Neural Network Based on Attention Mechanism and Feature Fusion Strategy for Apple Leaf Disease Classification by Tianyu Fang, Jialin Zhang, Dawei Qi, Mingyu Gao

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Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma by Xiangqian Zhang, Jie Wang, Hanyang Su, Xiaojin Liu

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Coupling Bio-Resonance Neurotechnology (BRNT) and Dual Hemispheric Repetitive Transcranial Magnetic Stimulation (rTMS) Reduces Comorbid Major Depressive Disorder (MDD) and Generali... by Sunder K, Makale MT, Makale M, Bodhanapati J, Murphy KT, Dennen CA, Baron D, Thanos PK, Hanna C, Ashford Jnr JW, Lewandrowski KU, Blum K

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Development and Validation of LAMP Assays for Distinguishing MPXV Clades with Fluorescent and Colorimetric Readouts by Nazente Atceken, Sara Asghari Dilmani, Ahmed Choukri Abdullah, Mutlu Sarıkaya, Defne Yigci, Gozde Korkmaz, Savas Tasoglu

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miR-24-3p/FGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression by Pengyu Jing, Nan Zhao, Nianlin Xie, Mingxiang Ye, Yong Zhang, Zhipei Zhang, Mengyang Li, Xiaofeng Lai, Jian Zhang, Zhongping Gu

“…Taken together, these findings define a novel insight into the miR-24-3p/FGFR3 signaling axis in regulating lung adenocarcinoma progression and suggest that targeting the miR-24-3p/FGFR3 axis could be an effective and efficient way to prevent tumor progression.…”
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A Novel 2.3 Mb Microduplication of 9q34.3 Inserted into 19q13.4 in a Patient with Learning Disabilities by Shalinder Singh, Fern Ashton, Renate Marquis-Nicholson, Jennifer M. Love, Chuan-Ching Lan, Salim Aftimos, Alice M. George, Donald R. Love

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A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. by Ellen T Heyman, Awais Ashfaq, Ulf Ekelund, Mattias Ohlsson, Jonas Björk, Ardavan M Khoshnood, Markus Lingman

“…<h4>Interpretation</h4>We designed a novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients by analysing unselected data from a complete regional health care system.…”
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Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid by Hidetaka Maegawa, Masayuki Kohashi, Yasuo Harada, Akira Tanaka, Shimpei Kajiwara, Takashi Fujimoto, Hidehiro Atagi, Kenta Kaneda

“…Abstract This study investigated whether intravenous administration of tumor cells killed by photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) had antitumor effects on distal tumors. Furthermore, a novel extracorporeal blood circulating 5-ALA/PDT system was developed. 5-ALA/PDT- (low or high irradiation) or anticancer drug–treated cells were intravenously administered to rats in a glioma cancer model. …”
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