Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a potential therapeutic agent by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Conclusion In our study, IRAK3, ITGBL1, and RHOU were identified as potential novel diagnostic and therapeutic targets for OA. …”
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A novel glucan from Sparassis latifolia: purification, structural characterization and protective effect on gastric mucosal cells against ethanol-induced damage by Mengyu Wang, Guoying Lv, Ruimeng Zhao, Weiming Cai, Zuofa Zhang

“…However, it remains unclear regarding the underlying regulatory mechanism of the gastroprotective effects of SLP. A novel polysaccharide SLP-2 was purified from the fruiting bodies of S. latifolia, and characterized using FT-IR, HPAEC, SEM, SEC–MALLS-RI, methylation, and NMR analysis. …”
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Novel approach to advance directive training: Hospice and palliative care fellow led workshop feasible and effective in increasing confidence in end of life conversations. by Chelsea Chang, Jose Cano, Juan Lopez-Alvarenga, Josenny Rodriguez-Paez, Sonya Montes, Rosa White, Meghana Rao

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Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán

“…Blocking galectin-9 improves rituximab efficacy, highlighting galectin-9 as a novel immunotherapeutic target in FL. In conclusion, FL-PDLS maintains the crosstalk between malignant B cells and the immune LN-TME and constitutes a robust and multiplexed pre-clinical tool to perform drug screening in a patient-derived system, advancing toward personalized therapeutic approaches.…”
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Synthesis, Molecular Docking, MEP and SAR Analysis, ADME-Tox Predictions, and Antimicrobial Evaluation of Novel Mono- and Tetra-Alkylated Pyrazole and Triazole Ligands by Y. Kaddouri, B. Bouchal, F. Abrigach, M. El Kodadi, M. Bellaoui, R. Touzani

“…All these findings suggested that these novel compounds represent promising antibacterial lead compounds.…”
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Erratum to “A Novel Method for Extraction of Galegine by Molecularly Imprinted Polymer (MIP) Technique Reinforced with Graphene Oxide and Its Evaluation Using Polarography” by M. Azimi, M. Ahmadi Golsefidi, A. Varasteh Moradi, M. Ebadi, R. Zafar Mehrabian

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Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Based on these clues, 24 novel non-covalent proteasome inhibitors (D01–D24) were finally designed and screened. …”
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Microwave assisted palladium catalyzed carbon-carbon bond formation to synthesise novel benzimidazole derivatives and their Photophysical properties, molecular docking, and DFT study by Vijayabharathi Sundharaj, S. Sarveswari

“…In the present study, novel benzimidazole compounds are synthesized, utilizing Suzuki coupling and acid-amine coupling reaction. …”
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Modification of hempseed protein isolate using a novel two-stage method applying high-pressure homogenization coupled with high-intensity ultrasound by Ruyu Zhang, Wangang Zhang, Xuan Dong, Meng Wai Woo, Siew Young Quek

“…Hempseed protein isolate (HPI), a novel plant protein, possesses advantages as an alternative food protein from a nutritional and sustainable perspective. …”
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A Novel Numerical Algorithm for Optimal Sizing of a Photovoltaic/Wind/Diesel Generator/Battery Microgrid Using Loss of Load Probability Index by Hussein A. Kazem, Tamer Khatib

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A Novel Design of Rescue Capsule considering the Pressure Characteristics and Thermal Dynamic Response with Thermomechanical Coupling Action Subjected to Gas Explosion Load by Xiaowei Zhai, Shibo Wu, Kai Wang, Xiaokun Chen, Haitao Li

“…To ensure the structural safety and reliability of coal mine rescue capsule in disastrous surroundings after gas explosion, in this paper, the thermomechanical coupling effect on a certain structure subjected to gas explosion was analyzed, and then a novel rescue capsule with a combination of radius and square features was designed according to the underground surroundings and relevant regulations on mine rescue devices. …”
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Synthesis and Anti-inflammatory Activity of Some Novel 2,4-Diaryl-3,5-bis(arylimino)-1,2,4-thiadiazolidine Derivatives by P. Venkatesh, S. N. Pandeya

“…A series of some novel 2,4-diaryl-3,5-bis(arylimino)-1,2,4-thiadiazolidine derivatives were synthesized and evaluated for anti-inflammatory activity. …”
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Exploring public support for novel tobacco and alcohol control policies in Great Britain 2021–2023: A population-based cross-sectional survey by Vera Helen Buss, Lion Shahab, Sharon Cox, Loren Kock, Melissa Oldham, Linda Bauld, Hazel Cheeseman, Garth Reid, Jamie Brown

“…Objective and rationale: This study assessed support for novel tobacco compared with alcohol control policies among adults in Great Britain in 2021–2023. …”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Here, we developed a human Tie2-agonistic antibody (MT-100) that not only resists Ang-2 antagonism and activates Tie2 signaling but also regulates a novel target, sushi repeat-containing protein X-linked 2 (Srpx2). …”
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Uric acid to albumin ratio is a novel predictive marker for all-cause and cardiovascular death in diabetic patients: a prospective cohort study by Shengnan Chen, Shengnan Chen, Ming Zhang, Shouye Hu, Xiaolong Shao, Lin Liu, Zhi Yang, Kai Nan

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Angiographic and Clinical Impact of Novel Revascularization for Occluded Femoropopliteal Prosthetic Bypass Graft: A Combination of Surgical Thrombectomy and Drug-Coated Balloon Angioplasty by Tatsuro Takei, Takashi Kajiya, Keisuke Yamamoto, Junichiro Takaoka, Yoshihiko Atsuchi, Nobuhiko Atsuchi

“…On further follow-up angiography, there was notable regression of the residual stenosis at the proximal anastomosis of the prosthetic graft. Conclusion. This novel revascularization strategy may be a viable treatment option for PFPBO.…”
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Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma by Wen-Yan Wang, Yue Chen, Qian Chen, Hong-Wei Sun, Nuo-Xuan Niu, Hong-Hui Li, Yu-Dan Cao, Yan-Xia Bai, Xiang Li, Xiang Li

“…AimThis study aims to create and validate a novel systematic immune-inflammation-nutrition (SIIN) score to provide a non-invasive and accurate prognostic tool for head and neck squamous cell carcinoma (HNSCC) patients.Methods259 participants diagnosed with HNSCC from the First Affiliated Hospital of Xi’an Jiaotong University between 2008 and 2017 was included in this retrospective study. …”
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Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors by Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai

“… Novel 1,3,4-oxadiazole derivatives were designed, synthesized by reaction of semicarbazide hydrochloride with thiophene-2-carbaldehyde to form semicarbazone that undergo iodine-mediated cyclization to form 5-(thiophen-2-yl)-1,3,4-oxadiazol-2-amine which further reacted with different aldehydes to form Schiff base derivatives, and in-vitro tested for their cytotoxic activity. …”
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A novel p.127Val>Ile single nucleotide polymorphism in the gene and its relation to litter size in Thin-tailed Indonesian ewes by Mutasem Abuzahra, Mohammed Baqur S. Al-Shuhaib, Dwi Wijayanti, Mustofa Helmi Effendi, Imam Mustofa, Ikechukwu Benjamin Moses

“…Results The study identified 19 novel SNPs, with 10 being non-synonymous variations, in the MTNR1A gene of Thin-tailed Indonesian ewes. …”
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Synthesis and Crystal Structure of Zn3(OAc)8[EMIM]2, a Novel Ionic Compound with Isolated Homoleptic Trinuclear Metal Clusters by Przemyslaw Dera, Edward Bruffey, Natalia Majewska, Isabella Kotsol, Phuong Q. H. Nguyen, Shelby Mitchell, Godwin Severa

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