Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

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Acute oral toxicity study of novel polyherbal formulations by using wistar rats and Swiss albino mice as per OECD 425 TG by Ramkishan Jatoth, S.P Dhanabal, V. Senthil, T. Ganesh, Jubie Selvaraj, P.S. Venkatesan

“…Acute oral toxicity is a primary safety profile of the novel polyherbal formulations. As a part of our study, we estimated acute toxicity safety profile of novel dosage forms by a Swiss albino mice and Wistar rats. …”
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Areas simultaneously susceptible and (dis-)connected to debris flows in the Dolomites (Italy): regional-scale application of a novel data-driven approach by Felix Pitscheider, Stefan Steger, Marco Cavalli, Francesco Comiti, Vittoria Scorpio

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Surgical Repair of the Postoperative Lung Hernia by Combining Mesh Interposition and Chest Wall Stabilization by Using Synthes Plates: A Novel Technique by Dragan Subotic, Mark Wiese, Aljaz Hojski, Didier Lardinois

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Novel disctete grey Bernoulli seasonal model with a time powter term for predicting monthly carbon dioxide emissions in the United States by Jianming Jiang, Yandong Ban, Sheng Nong

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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…Among the six VBDs, India is committed to the elimination of three (malaria, visceral leishmaniasis and lymphatic filariasis) and it will require additional and/or novel tools to overcome the roadblocks in our current journey to the goal of control/elimination of these VBDs.…”
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Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

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Research on a Novel Unsupervised-Learning-Based Pipeline Leak Detection Method Based on Temporal Kolmogorov–Arnold Network with Autoencoder Integration by Hengyu Wu, Zhu Jiang, Xiang Zhang, Jian Cheng

“…In this study, we propose a novel leak detector, which includes a new model and a sequence labeling method that integrates prior knowledge with traditional reconstruction error theory. …”
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CooccurrenceAffinity: An R package for computing a novel metric of affinity in co-occurrence data that corrects for pervasive errors in traditional indices by Kumar P. Mainali, Eric Slud

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Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents by Giannis Mountzios, Aspasia Soultati, Dimitrios Pectasides, Meletios A. Dimopoulos, Christos A. Papadimitriou

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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

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EduDCM: A Novel Framework for Automatic Educational Dialogue Classification Dataset Construction via Distant Supervision and Large Language Models by Changyong Qi, Longwei Zheng, Yuang Wei, Haoxin Xu, Peiji Chen, Xiaoqing Gu

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A novel hybrid methodology for wind speed and solar irradiance forecasting based on improved whale optimized regularized extreme learning machine by S. Syama, J. Ramprabhakar, R Anand, V. P. Meena, Josep M. Guerrero

“…Therefore, in order to ensure the safe RES integration providing high-quality power at a fair price and for the secure and reliable functioning of electrical systems, a precise one-day-ahead solar irradiation and wind speed forecast is essential for a stable and safe hybrid energy system. Here, we propose a novel hybrid methodology for wind speed and solar irradiance forecasting. …”
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A Novel Approach for Detection of Pavement Crack and Sealed Crack Using Image Processing and Salp Swarm Algorithm Optimized Machine Learning by Nhat-Duc Hoang, Thanh-Canh Huynh, Xuan-Linh Tran, Van-Duc Tran

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Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database by Kevin C. J. Yuen, Anna Camilla Birkegard, Lewis S. Blevins, David R. Clemmons, Andrew R. Hoffman, Nicky Kelepouris, Janice M. Kerr, Jens M. Tarp, Maria Fleseriu

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Leveraging computational approaches in identifying novel HER-2 + breast cancer potential therapeutics: integrating virtual screening and molecular dynamics simulation by Olawale Quadri Bolaji, Temitope Isaac Adelusi, Taiwo Ooreoluwa Ojo, Ibrahim Damilare Boyenle, Abdul-Quddus Kehinde Oyedele, Taiwo Temitope Ogunjobi, Adegboye Oyewole Oyaronbi, Sukurat Oluwatoyin Ayoola, Abdeen Tunde Ogunlana

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Novel Speech-Based Emotion Climate Recognition in Peers’ Conversations Incorporating Affect Dynamics and Temporal Convolutional Neural Networks by Ghada Alhussein, Mohanad Alkhodari, Ahsan H. Khandoker, Leontios J. Hadjileontiadis

“…Recognition of EC could provide an additional source in understating peers’ social interaction and behavior on top of peers’ actual conversational content.We propose a novel approach for speech-based EC recognition, termed AffECt, which combines peers’ complex affect dynamics (AD) with deep features extracted from speech signals using Temporal Convolutional Neural Networks (TCNNs). …”
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Novel 2D/3D Heterojunction for UV Light‐Emitting Diodes Using Hexagonal Boron Nitride as Hole Injection Layer by Andre Perepeliuc, Rajat Gujrati, Phuong Vuong, Vishnu Ottapilakkal, Thi May Tran, Mohamed Bouras, Ali Kassem, Ashutosh Srivastava, Tarik Moudakir, Gilles Patriarche, Paul Voss, Suresh Sundaram, Jean Paul Salvestrini, Abdallah Ougazzaden

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A novel mitochondrial-related risk model for predicting prognosis and immune checkpoint blockade therapy response in uterine corpus endometrial carcinoma by Ru-Gen Liao, Jin-Hong Wang, Fan Zhang, Yu-Tong Fang, Li Zhou, Yong-Qu Zhang

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A Novel Method for Adaptive Multiresonance Bands Detection Based on VMD and Using MTEO to Enhance Rolling Element Bearing Fault Diagnosis by Xingxing Jiang, Shunming Li, Chun Cheng

“…As a consequence, the novel method for enhancing rolling element bearing fault diagnosis is proposed. …”
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