Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia by Juan Li, Chunmei Ye, Hui Li, Jun Li

“…In vivo studies with cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) models demonstrated that CX-4945 and venetoclax combined therapy provided superior therapeutic efficacy, reducing tumor burden and prolonging survival compared to single-agent treatments.Conclusions IKZF1 represses BCL-2 in T-ALL, and targeting the CK2-IKZF1 axis with CX-4945 and venetoclax offers a promising therapeutic strategy, showing enhanced efficacy and potential as a novel treatment approach for T-ALL.…”
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Simulation of Daily Rainfall from Concurrent Meteorological Parameters over Core Monsoon Region of India: A Novel Approach by Utpal Misra, Atri Deshamukhya, Sanjay Sharma, Srimanta Pal

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Efficient Detection of West Nile Virus in Urine Specimens by a Novel In-House RT-qPCR Detection Kit by Gülten Tuncel, Gökçe Akan, Melis Kalaycı, Buket Baddal, Ayşegül Bostancı, Kaya Suer, Cenk Serhan Özverel, Tamer Şanlıdağ

“…Here, we present the development and validation of a novel RT-qPCR assay for precise and rapid detection of WNV RNA in urine, emerging as a promising specimen due to its noninvasive collection and high viral load. …”
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New food sources and production systems: a comparison of international regulations and China’s advancements in novel foods with synthetic biology by Xin Liu, Di Wu, Yi Shao, Yongning Wu

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Evaluation of the Antioxidant Properties and Biological Effects of a Novel Combined Barberry Root–Propolis Extract on HEK293T Cells by Dana Marcinčáková, Nikola Hudáková, Michal Miłek, Mária Kolesárová, Małgorzata Dżugan, Dasa Cizkova, Jaroslav Legáth

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A novel two-step process for enhancing adhesion strength of cold-spray metallization of carbon fiber-reinforced plastics by Jiayu Sun, Kenta Yamanaka, Chrystelle Bernard, Yuchao Lei, Shaoyun Zhou, Hao Lin, Kazuhiro Ogawa, Akihiko Chiba

“…However, the adhesion between the cold-sprayed metal deposits and CFRP substrate needs to be improved. In this study, a novel two-step strategy was developed to significantly enhance the adhesion strength of cold-sprayed Sn/epoxy-based CFRP interfaces. …”
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Publisher Correction: A novel sustainable biocide against the fruit fly Drosophila suzukii made from orange peels by Giovanni Davide Barone, Manfred Hartbauer

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A Novel Wild-Type <i>Lacticaseibacillus paracasei</i> Strain Suitable for the Production of Functional Yoghurt and Ayran Products by Ioanna Prapa, Chrysoula Pavlatou, Vasiliki Kompoura, Anastasios Nikolaou, Electra Stylianopoulou, George Skavdis, Maria E. Grigoriou, Yiannis Kourkoutas

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Screening and evaluation of novel DPP-IV inhibitory peptides in goat milk based on molecular docking and molecular dynamics simulation by Kuo Dang, Jing Lan, Yanli Wang, Daodong Pan, Lihui Du, Shikun Suo, Yali Dang, Xinchang Gao

“…By evaluating the docking energy and active sites, and by analyzing RMSD, RMSF, and Rg values, two novel peptides, GPFPLL and LPYPY, were successfully screened and identified. …”
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A Novel Approach for Stock Price Prediction Using Gradient Boosting Machine with Feature Engineering (GBM-wFE) by Rebwar M. Nabi, Soran Ab. M. Saeed, Habibollah Harron

“…This study proposes a novel multiclass classification ensemble learning approach for predicting stock prices based on historical data using feature engineering. …”
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Priestia flexa as a Novel Urinary Tract Pathogen in Daloa, Côte d’Ivoire: Insights From Genomic Sequencing by Dého Aristide Gbégbé, Okran Beyosse Christophe Kacou, N’goran Parfait N’zi, Djédoux Maxime Angaman

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Modified coke breeze distribution in iron ore sintering - a novel technique of reducing energy consumption and improving quality by Pal J., Prasad D., Venugopalan T.

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Novel exploration of topological degree method for noninstantaneous impulsive fractional integro-differential equation through the application of filtering system by Kanagaraj Muthuselvan, Baskar Sundaravadivoo, Shankar Rao Munjam, Kottakkaran Sooppy Nisar

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A novel inverter control strategy for maximum hosting capacity photovoltaic systems in distribution networks using power factor. by Ahmed Alfouly, Mohamed A Ismeil, I Hamdan

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A novel SS/Cu composite with bioinspired helical-lamellar-interpenetrated structure by direct ink writing and pressureless infiltration by Likai Yang, Bin Yuan, Junchi Cen, Jinhua He, Qiaoli Lin, Yu Shi

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Novel Ethyl 1,5-Disubstituted-1H-Pyrazole-3-Carboxylates as a New Class of Antimicrobial Agents by Radwan Awwad A., Ghorab Mostafa M., Alsaid Mansour S., Alanazi Fares K.

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A Novel Ionospheric Inversion Model: PINN‐SAMI3 (Physics Informed Neural Network Based on SAMI3) by Jiayu Ma, Haiyang Fu, J. D. Huba, Yaqiu Jin

“…To overcome this shortcoming, we propose a novel ionospheric inversion model, Physics‐Informed Neural Network based on fully physical models SAMI3 (PINN‐SAMI3). …”
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A novel TGFBR2 mutation causes Loeys-Dietz syndrome in a Chinese infant: A case report by Xin Liu, Kaiqing Liu, Lifu Hu, Zixiao Liu, Xinhua Liu, Jiantao Wang

“…Genetic analysis showed the patient carried a novel de novo TGF-β receptor 2 (TGFBR2) mutation (NM_003242: c.1005_1007delGTA (p.Glu335_Tyr336delinsAsp)). …”
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A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…In addition, we discovered that circANKRD17 has an open reading frame and can be translated into a novel 571-amino-acid protein that promotes lipid metabolism. …”
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Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer by Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang

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