AI-enhanced 3D-QSAR screening of fragment-based novel designed molecules targeting Phalaris minor ACCase by Bikash Kumar Rajak, Priyanka Rani, Durg Vijay Singh, Nitesh Singh

“…While herbicides are the primary solution to manage P. minor, their overuse has led to resistant biotypes, driving the need for novel herbicide molecules. Leveraging artificial intelligence (AI) and machine learning (ML) in the agritech revolution, researchers are now applying advanced computational techniques to identify and design effective ACCase inhibitors. …”
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Biodegradation of aflatoxin B1 by a novel mined aldo–keto reductase from Meyerozyma guilliermondii AF01 by Wan Zhang, Xiaojiao Chang, Yangying Han, Tiantian Li, Jianpeng Dou, Wen Du, Wenfu Wu, Wei Wang, Zhongjie Zhang, Changpo Sun

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The discovery and characterization of K‐563, a novel inhibitor of the Keap1/Nrf2 pathway produced by Streptomyces sp by Ran Hori, Kozo Yamaguchi, Hidetaka Sato, Miwa Watanabe, Kyoko Tsutsumi, Susumu Iwamoto, Masayuki Abe, Hideyuki Onodera, Satoshi Nakamura, Ryuichiro Nakai

“…Through this screening, we identified the novel Keap1/Nrf2 pathway inhibitor K‐563, which was isolated from actinomycete Streptomyces sp. …”
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A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome by Sujie Xiong, Guangyao Hu, Yao Zhou, Fei Sun, Yanlin Ma

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A novel wireless sensor network deployment for monitoring and predicting abnormal actions in medical environment and patient health state by R. Manikandan, S. Arunprakash, Rakan A. Alsowail, Tharani Pandiaraj

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A Novel Massive Big Data Analysis of Educational Examination Research Using a Linear Mixed-Effects Model by Jing Zhao, Yiwen Wang

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A New One-Dimensional Chaotic Map and Its Use in a Novel Real-Time Image Encryption Scheme by Radu Boriga, Ana Cristina Dăscălescu, Adrian-Viorel Diaconu

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Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

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A Novel Improved Threshold Adaptive Forgetting Variable Step Size Blind Separation Model for Weak Signal Detection by Tianyi Yu, Houming Wang, Shunming Li, Jiantao Lu, Siqi Gong, Yanfeng Wang, Guangrong Teng

“…In order to solve the abovementioned problems, a novel improved threshold adaptive forgetting variable step size blind separation model (ITAFBS) for weak signal detection is proposed. …”
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A Novel COL7A1 Mutation in a Patient With Dystrophic Epidermolysis Bullosa. Successful Treatment With Upadacitinib by Lai S, Lin C, Guo Z, Lai Y, Xie L, Wan C, Yang T, Li L

“…Here, we report a case of DEB caused by a mutation in the COL7A1 gene at a novel site, where the patient achieved favorable outcomes after treatment with upadacitinib. …”
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Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction by Marie-Claire Seeley, Howard O’Brien, Gemma Wilson, Clair Coat, Tess Smith, Kevin Hickson, Reynold Casse, Amanda J. Page, Celine Gallagher, Dennis H. Lau

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Numerical investigation on thermal-fractional characteristics inside a heated tube enhanced with a novel grooved cone turbulator by Bing Mei, Azher M. Abed, Pinank Patel, Ankit Kedia, Hamdi Ayed, Abir Mouldi, Ibrahim Mahariq

“…This study introduces a novel grooved cone turbulator (GCT) designed to enhance the thermal efficiency of a heated tube. …”
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A novel approach for solving bi-level mono-objective and multi-objective programming problems using evolutionary algorithms by Wafa Bouguern, Smail Addoune, Hanene Debbiche

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Novel cyclostationary multiple antenna spectrum sensing approach based on asymptotic optimal χ₂ test by Qing-lei KONG, Yu-long GAO

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Electrochemical Corrosion Prevention in Oilfield Wastewater for Effective Dissolved Oxygen Removal Using a Novel Upflow Bioelectrochemical System by Weilin Wu

“…However, an in situ biological technology for efficient DO removal has not been well developed by using organics in oilfield wastewater. A novel upflow bioelectrocatalytic system assembled with three electrodes (cathode-anode-cathode) was designed in this study, in which waste organic matter of oil wastewater was degraded by a bioanode for electron production and dissolved oxygen was efficiently reduced by a biocathode under an assistant external voltage. …”
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Analysis of spatial patellofemoral alignment using novel three-dimensional measurements based on weight-bearing cone-beam CT by Yurou Chen, Fan Yu, Fanzhuang Rong, Furong Lv, Fajin Lv, Jia Li

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Neonatal myoclonus in Bryant-Li-Bhoj syndrome associated with a novel H3F3A variant by Moemi Hojo, Noriko Soma, Kei Yamada, Yu Kobayashi, Masaki Miura, Hitomi Fujii, Hiromi Nyuzuki, Yosuke Nishio, Taichi Oso, Tomoo Ogi, Takeshi Ikeuchi, Jun Tohyama

“…Here, we present a Japanese patient with a novel heterozygous p.A48G variant in H3F3A, displaying previously unrecognized symptoms of neonatal myoclonus. …”
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A novel nanocarrier based on natural polyphenols enhancing gemcitabine sensitization ability for improved pancreatic cancer therapy efficiency by Yuman Dong, Jieru Li, Yiwei Dai, Xinyu Zhang, Xiangyan Jiang, Tao Wang, Bin Zhao, Wenbo Liu, Haonan Sun, Pengcheng Du, Long Qin, Zuoyi Jiao

“…In this study, we developed a novel PGG-based nanocarrier (FP) using a straightforward, one-step self-assembly method with Pluronic F127 and PGG. …”
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QUANTITATIVE STRUCTURE–ACTIVITY RELATIONSHIPS (QSAR) STUDY ON NOVEL 4-AMIDINOQUINOLINE AND 10-AMIDINOBENZONAPHTHYRIDINE DERIVATIVES AS POTENT ANTIMALARIA AGENT by Aliyu Wappah Mahmud, Gideon Adamu Shallangwa, Adamu Uzairu

“…Quantitative structure–activity relationships (QSAR) has been a reliable study in the development of models that predict biological activities of chemical substances based on their structures for the development of novel chemical entities. This  study was carried out on 44 compounds of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives to develop a model that relates their structures to their activities against Plasmodium falciparum. …”
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City of Wars: the Representation of Wartime London in Two Novels of the 1940s: James Hanley’s No Directions and Patrick Hamilton’s The Slaves of Solitude by Jean-Christophe Murat

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