Misuse of prescription medicines is as prevalent as the use of recreational drugs and novel psychoactive substances in Singapore: an unrecognised public health issue? by Wui Ling Chan, Paul Ivor Dargan, Colleen Michelle Haynes, Jody Lynn Green, Joshua Curtis Black, Richard Charles Dart, David Michael Wood

“…The survey collected information on participant demographics, and their awareness, self-reported lifetime and past-year misuse of commonly available prescription medicines in Singapore as well as the use of a range of recreational drugs and novel psychoactive substances (NPS). Results: Lifetime (6.7%) and past-year (4.8%) misuse of any prescription medicine was comparable to lifetime (6.0%) and past-year (3.0%) use of any recreational drugs/NPS. …”
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A novel approach to the convergence analysis of chaotic dynamics in fractional order Chua’s attractor model employing fixed points by Mudasir Younis, Haroon Ahmad, Mahpeyker Ozturk, Deepak Singh

“…This article uses a fixed point method to connect with Chua’s attractor model, incorporating the Atangana–Baleanu derivative using a two-step Lagrange polynomial. We introduce novel fixed point theorems using some special contractions followed by graphical representations of the convergence behavior of the iterative process. …”
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A novel ready-to-use loop-mediated isothermal amplification (LAMP) method for detection of Burkholderia mallei and B. pseudomallei by Mitsuru Nakase, Jeewan Thapa, Vanaabaatar Batbaatar, Ochirbat Khurtsbaatar, Batchuluun Enkhtuul, Jugderkhorloo Unenbat, Baasansuren Lkham, Sachiho Fujita, Ai Koshikawa, Apichai Tuanyok, Vannarat Saechan, Hideaki Higashi, Kyoko Hayashida, Yasuhiko Suzuki, Chie Nakajima, Takashi Kimura

“…This primer set did not detect any other Burkholderia species. Using this novel primer set, a dried-format in-house LAMP method with high sensitivity and specificity was developed. …”
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The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells by Shuhd Bin Eshaq, Jalal Taneera, Shabana Anjum, Abdul Khader Mohammed, Mohammad H. Semreen, Karem H. Alzoubi, Mohamed Eladl, Yasser Bustanji, Eman Abu-Gharbieh, Waseem El-Huneidi

“…In summary, this study provides novel insights into the role of AhR in maintaining proper β-cell function. …”
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Design of a novel Cu-Cr-X alloy with high strength and high electrical conductivity based on mechanical learning by Yunqing Zhu, Yicheng Cao, Lijun Peng, Qian Yu, Zhen Yang, Zengde Li, Junsheng Wu, Haofeng Xie

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Novel EDAS Methodology Based on Single-Valued Neutrosophic Aczel-Alsina Aggregation Information and Their Application in Complex Decision-Making by Shahzaib Ashraf, Shakoor Ahmad, Muhammad Naeem, Muhammad Riaz, Md. Ashraful Alam

“…To accomplish our goal, we first extend the Aczel-Alsina t-norm and t-conorm to SVN scenarios and introduce a few new SVN operations on which we construct novel SVN aggregation operators. Furthermore, a decision support strategy is built in the SVN framework using the EDAS methodology and the suggested Aczel-Alsina aggregation operators. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…We previously identified a novel HDAC5 inhibitor, T2943, with antidepressant properties that promote histone 3 lysine-14 acetylation (H3K14ac) by inhibiting HDAC5 activity. …”
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Exploration of the molecular mechanism behind a novel natural genic male-sterile mutation of 1205A in Brassica napus by Lijing Xiao, Jinze Zhang, Shaomin Guo, Hairun Jin, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

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Bearing Fault Diagnosis Using a Novel Classifier Ensemble Based on Lifting Wavelet Packet Transforms and Sample Entropy by Lei Zhang, Long Zhang, Junfeng Hu, Guoliang Xiong

“…Such a feature extraction paradigm is expected to depict complexity, irregularity, and nonstationarity of bearing vibrations. Moreover, a novel classifier ensemble is proposed to alleviate the effect of initial parameters on the performance of member classifiers and to improve classification effectiveness. …”
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The Evaluation of the Efficacy of a Novel Subunit Vaccine in the Prevention of <i>Cryptosporidium parvum</i>-Caused Diarrhoea in Neonatal Calves by Martine Reijnders, Mark van Roosmalen, Hans Holtslag, Susan Arts, Suzanne Pel, Divine Dufé, Marianne Kaashoek, Geert Vertenten, Tine van Werven, Steven Sietsma, Christophe Roy, Nicolas Herman

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Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

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A Novel Convex Hull Coverage Algorithm for the Deployment of Electric Taxi Swap Stations Based on Urban Traffic Flow by Xudong Zhu, Lijun Yao, Yuxin Mao, Renjie Wang, Hanxiao Shi, Ji Qi

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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…In this study, we identified the key gene RACK1 and its novel mutation RACK1-p.L206P as being associated with seizures through single-cell transcriptome sequencing (scRNA-seq) and whole exome sequencing (WES) techniques. …”
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RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications by Reza Eivazzadeh-Keihan, Farkhondeh Alimirzaloo, Hooman Aghamirza Moghim Aliabadi, Ehsan Bahojb Noruzi, Ali Reza Akbarzadeh, Ali Maleki, Hamid Madanchi, Mohammad Mahdavi

“…Abstract In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials. …”
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Retraction Note: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications by Reza Eivazzadeh-Keihan, Farkhondeh Alimirzaloo, Hooman Aghamirza Moghim Aliabadi, Ehsan Bahojb Noruzi, Ali Reza Akbarzadeh, Ali Maleki, Hamid Madanchi, Mohammad Mahdavi

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A novel way to use cross-validation to measure connectivity by machine learning allows epilepsy surgery outcome prediction by Karla Ivankovic, Alessandro Principe, Justo Montoya-Gálvez, Linus Manubens-Gil, Riccardo Zucca, Pablo Villoslada, Mara Dierssen, Rodrigo Rocamora

“…To test this hypothesis, we developed a novel method for quantifying connectivity change between network states and applied it to identify surgical resection areas.A network state was represented by random snapshots of connectivity within a defined time interval of an intracranial EEG recording. …”
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Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…We also highlighted the novel role of the Pin1-cis P-tau-ApoE axis in the development of preE, and propagation of cis P-tau-mediated abnormal protein aggregation (tauopathy) from the placenta to cerebral tissues later in life, leading to neurodegenerative conditions. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

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Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

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Computational identification and experimental validation of novel Saccharum officinarum microRNAs along with their targets through RT-PCR approach by Abdul Baqi, Samiullah, Jadoon Khan, Asma Sadiq, Yousaf Khan, Shahid Ali, Syed Nadeem ul Hassan Mohani, Naqeebullah Khan, Tawaf Ali Shah, Khalid S. Almaary, Youssouf Ali Younous, Mohammed Bourhia

“…This study seeks to identify and partially characterize several novel miRNAs in sugarcane using in silico tools, while also offering a preliminary assessment of their functions. …”
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