Comparison of remineralizing efficacy of two novel preparation of arginine and theobromine on white spot lesion - an in vitro SEM analysis by Shifo Savio F, Nivethigaa Balakrishnan, Aravind Kumar Subramanian

“…Purpose Evaluation of the efficacy of two novel formulations of arginine and theobromine in remineralizing artificial enamel defects using in vitro testing techniques- Microhardness and SEMMaterials and methods Enamel slabs measuring 3 mm by 3 mm by 1.5 mm were created using 11 healthy premolars that were excised for orthodontic treatment. …”
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Phytosynthesized Nanoparticles as Novel Antifungal Agent for Sustainable Agriculture: A Mechanistic Approach, Current Advances, and Future Directions by Javeria Parveen, Tahira Sultana, Abeer Kazmi, Khafsa Malik, Abd Ullah, Amir Ali, Bushra Qayyum, Naveed Iqbal Raja, Zia-ur-Rehman Mashwani, Saif Ur Rehman

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A Novel Hydraulic Interconnection Design and Sliding Mode Synchronization Control of Leveling System for Crawler Work Machine by Ruochen Wang, Kaiqiang Zhang, Renkai Ding, Yu Jiang, Yiyong Jiang

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A novel detection method for warhead fragment targets in optical images under dynamic strong interference environments by Guoyi Zhang, Hongxiang Zhang, Zhihua Shen, Deren Kong, Chenhao Ning, Fei Shang, Xiaohu Zhang

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The Anti-Inflammatory Activity of a Novel Fused-Cyclopentenone Phosphonate and Its Potential in the Local Treatment of Experimental Colitis by Dorit Moradov, Helena Shifrin, Efrat Harel, Mirela Nadler-Milbauer, Marta Weinstock, Morris Srebnik, Abraham Rubinstein

“…A novel fused-cyclopentenone phosphonate compound, namely, diethyl 3-nonyl-5-oxo-3,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-4-ylphosphonate (P-5), was prepared and tested in vitro (LPS-activated macrophages) for its cytotoxicity and anti-inflammatory activity and in vivo (DNBS induced rat model) for its potential to ameliorate induced colitis. …”
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Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis by M. Beter, H. H. Pulkkinen, T. Örd, A. Sormunen, L. Kilpeläinen, J. E. Dunford, M. U. Kaikkonen, E. Aavik, N. Laham-Karam, U. Oppermann, J. P. Laakkonen, S. Ylä-Herttuala

“…We identified two epigenetic enzyme inhibitors as novel regulators of sprouting angiogenesis: A196, a selective SUV4-20H1/H2 inhibitor, demonstrated pro-angiogenic effects through increased H4K20me1 levels and upregulation of cell cycle associated genes, including MCM2 and CDK4. …”
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A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography by Ming-xu Zhu, Jun-yao Li, Zhan-xiu Cai, Yu Wang, Wei-ce Wang, Yi-tong Guo, Guo-bin Gao, Qing-dong Guo, Xue-tao Shi, Wei-chen Li

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Identification of novel clinical subtypes in patients with microscopic polyangiitis using cluster analysis: multicenter REVEAL cohort study by Ayana Okazaki, Shogo Matsuda, Takuya Kotani, Keisuke Fukui, Keisuke Fukui, Takaho Gon, Ryu Watanabe, Atsushi Manabe, Mikihito Shoji, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto, Tohru Takeuchi

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Screening and identification of two novel phosphate-solubilizing Pyrenochaetopsis tabarestanensis strains and their role in enhancing phosphorus uptake in rice by Xiaozhe Bao, Haifei Lu, Jinyao Zhao, Taotao Yang, Longmei Wu, Jixiang Zou, Qingchun Chen, Bin Zhang

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A Novel Extended Susceptible, Exposed, Infected, and Recovered Model with Surveys for Analysis of COVID-19 Pandemic in Rajasthan by Meena Malik, Chander Prabha, Punit Soni, Khushboo Bhardwaj, Anshu Arora

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A novel nano-emulsion cream of casein isolated from raw milk for thermal and acid burn wounds by Shivani Shrivastava, Saumya Das, Chanchal Sharma, Archna Singh, Sanjita Das, Manas Kumar Das, Pankaj Kumar Tyagi, Navneet Khurana

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Mapping of Novel QTL Regulating Grain Shattering Using Doubled Haploid Population in Rice (Oryza sativa L.) by Gyu-Ho Lee, In-Kyu Kang, Kyung-Min Kim

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Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

“…Objective To investigate differential associations of traditional and novel adiposity indices with visual impairment (VI) in the middle-aged and older Chinese population.Methods and analysis Based on the China Health and Retirement Longitudinal Study, 7750 Chinese older adults aged over 45 were included at baseline 2011, and 4133 participants who accomplished all three interviews from 2011 to 2015 were adapted for longitudinal analyses. …”
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A novel source of phytochemical and bioactive peptide from fermented mushroom trimming waste extract by Bifidobacterium longum by Napassorn Peasura, Pornrat Sinchaipanit, Kanokwan Yodin

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A novel model of the cross-section variation effect induced by contraction convection on freckle defects in directional solidification by Yang Liu, Yan Shang, Fu Wang, Dexin Ma, Qiang Yang, Xiaorui Chen, Jiantao Wu

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A Novel Mechanism-Equivalence-Based Tweedie Exponential Dispersion Process for Adaptive Degradation Modeling and Life Prediction by Jiayue Wu, Yujie Liu, Han Wang, Xiaobing Ma, Yu Zhao

“…To address these issues, we propose a novel mechanism-equivalence-based Tweedie exponential dispersion process (ME-based TEDP) for adaptive degradation modeling and RUL prediction of mechanical components. …”
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Novel BN-COOH@ZrO2/GO Composite for Enhanced Electrical Conductivity and Electrochemical Detection of Diclofenac by Vivek Kumar, Ankit Kumar Singh, Ida Tiwari, Lallan Mishra

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Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…The unique exon ten at the dimer-dimer interface represents an attractive target for isoform-specific modulation, offering opportunities for disrupting this equilibrium and altering tumour cell dynamics.This study identifies a novel druggable pocket at the PKM2 dimer interface through conformational analysis. …”
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