Episodic ataxia type 2 with a novel missense variant (Leu602Arg) in CACNA1A by Shiroh Miura, Emina Watanabe, Kensuke Senzaki, Shigeyoshi Hiruki, Sayaka Matsumoto, Takuya Morikawa, Yusuke Uchiyama, Seiji Kurata, Masayuki Ochi, Yasumasa Ohyagi, Hiroki Shibata

“…Cerebellar atrophy was not evident, but single photon emission computed tomography showed cerebellar hypoperfusion. We identified a novel nonsynonymous variant in CACNA1A, NM_001127222.2:c.1805T>G (p.Leu602Arg), which is predicted to be functionally deleterious; therefore, this variant is likely responsible for EA2 in this pedigree.…”
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Selective fluoride ion sensing using novel quinoline chemosensor insights into kinetics and molecular logic gate functions by A. V. Ashwathi, Sabeel M. Basheer

“…Abstract CQHC, a novel colorimetric fluorescent sensor, developed for the selective sensing of ions and well characterised, including SC-XRD. …”
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Identification and functional analysis of a novel SMARCC2 splicing variant in a family with syndromic neurodevelopmental disorder by Ming Li, Jingqi Lin, Hongjun Fei, Jinyu Liu, Yiyao Chen, Xu Han, Yanlin Wang, Jian Wang, Renyi Hua, Shuyuan Li, Niu Li

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A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy by Annik Prat, Maik Behrendt, Edwige Marcinkiewicz, Sebastien Boridy, Ram M. Sairam, Nabil G. Seidah, Dusica Maysinger

“…The aim of the present study was to explore the abnormalities of neural cells in a novel mouse model of AD with chronic estrogen deficiency. …”
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Genome sequence of Novosphingobium malaysiense strain MUSC 273T, novel alpha-proteobacterium isolated from intertidal soil by Hooi-Leng Ser, Wai-Fong Yin, Kok-Gan Chan, Nurul-Syakima Ab Mutalib, Learn-Han Lee

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A Dual-Port Dual-Wideband Dual-Sense Circularly Polarized DRA With a Novel Feeding Mechanism by Li Zhang, Jian-Wei Liu, Bo Chen, Liang-Yong Yi, Dian Liu, Zi-Bin Weng, Yong-Chang Jiao

“…A dual-wideband dual-sense circularly polarized (CP) dielectric resonator antenna (DRA) based on a novel feeding technique is investigated and demonstrated. …”
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Inverse Position Solution and Workspace Analysis of a Novel 3T2R Redundantly Actuated Hybrid Mechanism by Wang Shusen, Mei Ying, Li Ruiqin

“…A novel 3T2 R redundantly actuated hybrid mechanism is proposed. …”
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Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels by Itsuro Kazama

“…Based on the recent in vitro evidence that revealed the pharmacological properties of the channels, the most recent studies have revealed novel therapeutic implications of targeting the lymphocyte Kv1.3-channels for the treatment of renal diseases.…”
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Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…This study, for the first time, identifies a novel ubiquitin ligase, FBXO4 that targets the degradation of HPV E6 oncoprotein in the absence of E6AP in cervical cancer-derived cell lines. …”
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Ascospore discharge, germination and culture of fungal partners of tropical lichens, including the use of a novel culture technique by E. Sangvichien, D.L. Hawksworth, A.J.S. Whalley

“…The most successful medium tried was 2 % Malt-Yeast extract agar (MYA), and under static conditions using a liquid culture medium, a sponge proved to be the best of several physical carriers tested; this novel method has considerable potential for experimental work with lichen mycobionts.…”
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Enhancing Intelligent Road Target Monitoring: A Novel BGS-YOLO Approach Based on the YOLOv8 Algorithm by Xingyu Liu, Yuanfeng Chu, Yiheng Hu, Nan Zhao

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The feasibility of a novel national quality improvement programme for tobacco dependency treatment pathways in acute UK hospitals by Robyn Fletcher, Alexander Hammant, Christina Moll, Miguel Souto, Sanjay Agrawal

“…Other programme outcomes included increases in QI knowledge, confidence and attitudes along with enhanced project management skills. Conclusion: This novel, national, online QI programme supported participating multidisciplinary teams in acute trusts across the UK to deliver tobacco dependency treatment pathway improvements using QI tools and methodology. …”
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Evaluation of a Novel Method of Teaching Endobronchial Ultrasound: Physician- Versus Respiratory Therapist-Proctored Simulation Training by David Ryan Stather, Alex Chee, Paul MacEachern, Elaine Dumoulin, Christopher A Hergott, Jacob Gelberg, Sandra D Scott, Sylvia De Guzman, Alain Tremblay

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Targeted s-gram matching: a novel n-gram matching technique for cross- and monolingual word form variants by Ari Pirkola, Heikki Keskustalo, Erkka Leppänen, Antti-Pekka Känsälä, Kalervo Järvelin

“…We present a novel n-gram based string matching technique, which we call the targeted s-gram matching technique. …”
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Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

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Novel Orthobiologic Preparation and Regenerative Rehabilitation of a Complex Shoulder Injury in a Competitive Adolescent Female Athlete by James Escaloni, Danesh Mazloomdoost, Ian Young

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Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment by Katherine M. Ranard, Bruce Appel

“…Embryos undergo rapid external development and are optically transparent, enabling direct observation of individual cells and dynamic cell-cell interactions in a way that is not possible in rodents. Here, we create a novel DHA-deficient zebrafish model by 1) disrupting elovl2, a key gene in the DHA biosynthesis pathway, via CRISPR/Cas9 genome editing, and 2) feeding mothers a DHA-deficient diet. …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

“…Targeting more variable allosteric sites, which are spatially different from the highly conserved orthosteric sites, represents a novel approach in biased GPCR drug discovery, leading to innovative strategies for targeting GPCRs. …”
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A Novel Algorithm Combining Finite State Method and Genetic Algorithm for Solving Crude Oil Scheduling Problem by Qian-Qian Duan, Gen-Ke Yang, Chang-Chun Pan

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Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract by Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu

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