Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome
Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL). IgA anti-β2 Glycoprotein I (aB2-GPI) antibodies a...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/704395 |
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| author | Raquel Ruiz-García Manuel Serrano José Ángel Martínez-Flores Sergio Mora Luis Morillas María Ángeles Martín-Mola José M. Morales Estela Paz-Artal Antonio Serrano |
| author_facet | Raquel Ruiz-García Manuel Serrano José Ángel Martínez-Flores Sergio Mora Luis Morillas María Ángeles Martín-Mola José M. Morales Estela Paz-Artal Antonio Serrano |
| author_sort | Raquel Ruiz-García |
| collection | DOAJ |
| description | Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL). IgA anti-β2 Glycoprotein I (aB2-GPI) antibodies are associated with APS. However, they are not currently considered to be laboratory criteria due to the heterogeneity of published works and the use of poor standardized diagnostic systems. We have aimed to assess aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies. Only 14% of patients with C-APS were positive for any consensus antibody, whereas the presence of isolated IgA aB2GPI antibodies was found in 22% of C-APS patients. In patients with arterial thrombosis IgA aB2GPI, antibodies were the only aPL antibodies present. Serologic profile in primary APS (PAPS) is different from systemic autoimmune disorders associated APS (SAD-APS). IgA aB2GPI antibodies are more prevalent in PAPS and IgG aB2GPI antibodies are predominant in SAD-APS. The analysis of IgA aB2GPI antibodies in patients with clinical manifestations of PAPS might avoid underdiagnosed patients and provide a better diagnosis in patients with SAD-APS. Laboratory consensus criteria might consider including analysis of IgA aB2GPI for APS diagnosis. |
| format | Article |
| id | doaj-art-fffa99b305374296bf544b0212538d25 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fffa99b305374296bf544b0212538d252025-02-03T01:12:35ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/704395704395Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid SyndromeRaquel Ruiz-García0Manuel Serrano1José Ángel Martínez-Flores2Sergio Mora3Luis Morillas4María Ángeles Martín-Mola5José M. Morales6Estela Paz-Artal7Antonio Serrano8Servicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Nefrología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Reumatología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Hematología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Nefrología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainServicio de Inmunología, Instituto de Investigación Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041 Madrid, SpainSeronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL). IgA anti-β2 Glycoprotein I (aB2-GPI) antibodies are associated with APS. However, they are not currently considered to be laboratory criteria due to the heterogeneity of published works and the use of poor standardized diagnostic systems. We have aimed to assess aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies. Only 14% of patients with C-APS were positive for any consensus antibody, whereas the presence of isolated IgA aB2GPI antibodies was found in 22% of C-APS patients. In patients with arterial thrombosis IgA aB2GPI, antibodies were the only aPL antibodies present. Serologic profile in primary APS (PAPS) is different from systemic autoimmune disorders associated APS (SAD-APS). IgA aB2GPI antibodies are more prevalent in PAPS and IgG aB2GPI antibodies are predominant in SAD-APS. The analysis of IgA aB2GPI antibodies in patients with clinical manifestations of PAPS might avoid underdiagnosed patients and provide a better diagnosis in patients with SAD-APS. Laboratory consensus criteria might consider including analysis of IgA aB2GPI for APS diagnosis.http://dx.doi.org/10.1155/2014/704395 |
| spellingShingle | Raquel Ruiz-García Manuel Serrano José Ángel Martínez-Flores Sergio Mora Luis Morillas María Ángeles Martín-Mola José M. Morales Estela Paz-Artal Antonio Serrano Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome Journal of Immunology Research |
| title | Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome |
| title_full | Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome |
| title_fullStr | Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome |
| title_full_unstemmed | Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome |
| title_short | Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome |
| title_sort | isolated iga anti β2 glycoprotein i antibodies in patients with clinical criteria for antiphospholipid syndrome |
| url | http://dx.doi.org/10.1155/2014/704395 |
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