Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure
This study was conducted to investigate the protective effects of Apis dorsata honey on the histopathological changes of the kidney in mice exposed to monosodium glutamate. This study used 25 male mice as the experimental animal which were divided into five groups with five replication, respectively...
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| Format: | Article |
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Universitas Airlangga, Faculty of Veterinary Medicine
2023-12-01
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| Series: | Jurnal Medik Veteriner |
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| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/46242 |
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| author | Sherbrina Bai Seenivasa Rao Widjiati Widjiati Widya Paramita Lokapirnasari Nusdianto Triakoso Erma Safitri Suryo Kuncorojakti Annise Proboningrat |
| author_facet | Sherbrina Bai Seenivasa Rao Widjiati Widjiati Widya Paramita Lokapirnasari Nusdianto Triakoso Erma Safitri Suryo Kuncorojakti Annise Proboningrat |
| author_sort | Sherbrina Bai Seenivasa Rao |
| collection | DOAJ |
| description | This study was conducted to investigate the protective effects of Apis dorsata honey on the histopathological changes of the kidney in mice exposed to monosodium glutamate. This study used 25 male mice as the experimental animal which were divided into five groups with five replication, respectively i.e. (C-) was administered basal diet, (C+) was administered 4 mg/g BW MSG, (T1) was administered A. dorsata honey of 53.82 mg/20g BW followed by MSG 4 mg/g BW, (T2) was administered A. dorsata honey of 107.64 mg/20g BW followed by MSG 4 mg/g BW, and (T3) was administered A. dorsata honey of 161.46 g/20g BW followed by MSG 4 mg/g BW. All treatments were carried out orally for 52 days. This study was observed tubular epithelial hydropic degeneration, epithelial necrosis, and glomerular necrosis. Data were analyzed using Kruskal-Wallis test followed by the Mann-Whitney test. As a result, for the epithelial and glomerular necrosis variables, the T3 group showed significant results when compared with C+, T1, and T2 groups. Moreover, T3 was not significantly different from the C- group. It can be concluded that A. dorsata honey in T3 group could protect mice kidneys from the damaging effect of MSG. |
| format | Article |
| id | doaj-art-fff24a5740e445379ffaaaa77af2346d |
| institution | Kabale University |
| issn | 2615-7497 2581-012X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj-art-fff24a5740e445379ffaaaa77af2346d2025-02-03T10:49:58ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2023-12-0163636910.20473/jmv.vol6.iss3.2023.63-6944328Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate ExposureSherbrina Bai Seenivasa Rao0https://orcid.org/0000-0002-3150-5103Widjiati Widjiati1https://orcid.org/0000-0002-8376-1176Widya Paramita Lokapirnasari2https://orcid.org/0000-0003-3740-0836Nusdianto Triakoso3https://orcid.org/0000-0001-8644-5833Erma Safitri4https://orcid.org/0000-0002-6817-1178Suryo Kuncorojakti5https://orcid.org/0000-0001-5170-9982Annise Proboningrat6https://orcid.org/0000-0001-7939-9402Bachelor Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaThis study was conducted to investigate the protective effects of Apis dorsata honey on the histopathological changes of the kidney in mice exposed to monosodium glutamate. This study used 25 male mice as the experimental animal which were divided into five groups with five replication, respectively i.e. (C-) was administered basal diet, (C+) was administered 4 mg/g BW MSG, (T1) was administered A. dorsata honey of 53.82 mg/20g BW followed by MSG 4 mg/g BW, (T2) was administered A. dorsata honey of 107.64 mg/20g BW followed by MSG 4 mg/g BW, and (T3) was administered A. dorsata honey of 161.46 g/20g BW followed by MSG 4 mg/g BW. All treatments were carried out orally for 52 days. This study was observed tubular epithelial hydropic degeneration, epithelial necrosis, and glomerular necrosis. Data were analyzed using Kruskal-Wallis test followed by the Mann-Whitney test. As a result, for the epithelial and glomerular necrosis variables, the T3 group showed significant results when compared with C+, T1, and T2 groups. Moreover, T3 was not significantly different from the C- group. It can be concluded that A. dorsata honey in T3 group could protect mice kidneys from the damaging effect of MSG.https://e-journal.unair.ac.id/JMV/article/view/46242apis dorsatahealthhoneykidneymonosodium glutamate |
| spellingShingle | Sherbrina Bai Seenivasa Rao Widjiati Widjiati Widya Paramita Lokapirnasari Nusdianto Triakoso Erma Safitri Suryo Kuncorojakti Annise Proboningrat Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure Jurnal Medik Veteriner apis dorsata health honey kidney monosodium glutamate |
| title | Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure |
| title_full | Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure |
| title_fullStr | Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure |
| title_full_unstemmed | Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure |
| title_short | Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure |
| title_sort | protective effects of apis dorsata honey supplementation on kidney histopathology in mice with monosodium glutamate exposure |
| topic | apis dorsata health honey kidney monosodium glutamate |
| url | https://e-journal.unair.ac.id/JMV/article/view/46242 |
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