Trophic Factors from Tissue Stem Cells for Renal Regeneration
Stem cell therapies against renal injury have been advancing. The many trials for renal regeneration are reported to be effective in many kinds of renal injury models. Regarding the therapeutic mechanism, it is believed that stem cells contribute to make regeneration via not only direct stem cell di...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/537204 |
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| _version_ | 1832556792204230656 |
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| author | Kenji Tsuji Shinji Kitamura |
| author_facet | Kenji Tsuji Shinji Kitamura |
| author_sort | Kenji Tsuji |
| collection | DOAJ |
| description | Stem cell therapies against renal injury have been advancing. The many trials for renal regeneration are reported to be effective in many kinds of renal injury models. Regarding the therapeutic mechanism, it is believed that stem cells contribute to make regeneration via not only direct stem cell differentiation in the injured space but also indirect effect via secreted factors from stem cells. Direct differentiation from stem cells to renal composed cells has been reported. They differentiate to renal composed cells and make functions. However, regarding renal regeneration, stem cells are discussed to secrete many kinds of growth factors, cytokines, and chemokines in paracrine or autocrine manner, which protect against renal injury, too. In addition, it is reported that stem cells have the ability to communicate with nearby cells via microvesicle-related RNA and proteins. Taken together from many reports, many secreted factors from stem cells were needed for renal regeneration orchestrally with harmony. In this review, we focused on the effects and insights of stem cells and regenerative factors from stem cells. |
| format | Article |
| id | doaj-art-fff0427392fd4c22b7158feee5639474 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-fff0427392fd4c22b7158feee56394742025-02-03T05:44:30ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/537204537204Trophic Factors from Tissue Stem Cells for Renal RegenerationKenji Tsuji0Shinji Kitamura1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho, Okayama, Okayama 700-8558, JapanDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho, Okayama, Okayama 700-8558, JapanStem cell therapies against renal injury have been advancing. The many trials for renal regeneration are reported to be effective in many kinds of renal injury models. Regarding the therapeutic mechanism, it is believed that stem cells contribute to make regeneration via not only direct stem cell differentiation in the injured space but also indirect effect via secreted factors from stem cells. Direct differentiation from stem cells to renal composed cells has been reported. They differentiate to renal composed cells and make functions. However, regarding renal regeneration, stem cells are discussed to secrete many kinds of growth factors, cytokines, and chemokines in paracrine or autocrine manner, which protect against renal injury, too. In addition, it is reported that stem cells have the ability to communicate with nearby cells via microvesicle-related RNA and proteins. Taken together from many reports, many secreted factors from stem cells were needed for renal regeneration orchestrally with harmony. In this review, we focused on the effects and insights of stem cells and regenerative factors from stem cells.http://dx.doi.org/10.1155/2015/537204 |
| spellingShingle | Kenji Tsuji Shinji Kitamura Trophic Factors from Tissue Stem Cells for Renal Regeneration Stem Cells International |
| title | Trophic Factors from Tissue Stem Cells for Renal Regeneration |
| title_full | Trophic Factors from Tissue Stem Cells for Renal Regeneration |
| title_fullStr | Trophic Factors from Tissue Stem Cells for Renal Regeneration |
| title_full_unstemmed | Trophic Factors from Tissue Stem Cells for Renal Regeneration |
| title_short | Trophic Factors from Tissue Stem Cells for Renal Regeneration |
| title_sort | trophic factors from tissue stem cells for renal regeneration |
| url | http://dx.doi.org/10.1155/2015/537204 |
| work_keys_str_mv | AT kenjitsuji trophicfactorsfromtissuestemcellsforrenalregeneration AT shinjikitamura trophicfactorsfromtissuestemcellsforrenalregeneration |