Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres
Sustained release of anesthesia has shown great promise in the treatment of chronic pain in patients. In this research, we used neutralized ropivacaine as an anesthesia and poly(ε-caprolactone) (PCL) with different architectures to systematically study how these architectures affect the release of r...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2019/1412737 |
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| author | Wei Xiong Yue-kun Shen Peng Dong Ying Xiao Xiong-qing Huang Wen-qi Huang Lu Yang Xia Feng |
| author_facet | Wei Xiong Yue-kun Shen Peng Dong Ying Xiao Xiong-qing Huang Wen-qi Huang Lu Yang Xia Feng |
| author_sort | Wei Xiong |
| collection | DOAJ |
| description | Sustained release of anesthesia has shown great promise in the treatment of chronic pain in patients. In this research, we used neutralized ropivacaine as an anesthesia and poly(ε-caprolactone) (PCL) with different architectures to systematically study how these architectures affect the release of ropivacaine. After optimizing the parameters of the preparation of microspheres, ropivacaine-loaded 1-PCL microspheres and 4-PCL microspheres were obtained. Fourier Transform infrared spectra (FT-IR) and X-ray diffraction spectra (XRD) confirmed that ropivacaine was encapsulated within the microsphere rather than inserted on the surface of the microsphere. Ropivacaine was found to be buried deeper in the 1-PCL microsphere than in the 4-PCL microsphere. In vitro release assay revealed that small crystalline grains interfered with ropivacaine release in 4-PCL microspheres during the initial release period, but then two kinds of microspheres showed a similar ropivacaine release rate. We basically proved that the architecture of PCL has a negligible effect on ropivacaine release. Cell proliferation test revealed that the release of products from the microspheres resulted in insignificant toxicity towards mammalian cells. |
| format | Article |
| id | doaj-art-ffc144b8e2c043878f4fd38e08ded2f4 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ffc144b8e2c043878f4fd38e08ded2f42025-02-03T06:06:09ZengWileyInternational Journal of Polymer Science1687-94221687-94302019-01-01201910.1155/2019/14127371412737Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) MicrospheresWei Xiong0Yue-kun Shen1Peng Dong2Ying Xiao3Xiong-qing Huang4Wen-qi Huang5Lu Yang6Xia Feng7Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, 510070 Guangzhou, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, Guangdong Province, ChinaSustained release of anesthesia has shown great promise in the treatment of chronic pain in patients. In this research, we used neutralized ropivacaine as an anesthesia and poly(ε-caprolactone) (PCL) with different architectures to systematically study how these architectures affect the release of ropivacaine. After optimizing the parameters of the preparation of microspheres, ropivacaine-loaded 1-PCL microspheres and 4-PCL microspheres were obtained. Fourier Transform infrared spectra (FT-IR) and X-ray diffraction spectra (XRD) confirmed that ropivacaine was encapsulated within the microsphere rather than inserted on the surface of the microsphere. Ropivacaine was found to be buried deeper in the 1-PCL microsphere than in the 4-PCL microsphere. In vitro release assay revealed that small crystalline grains interfered with ropivacaine release in 4-PCL microspheres during the initial release period, but then two kinds of microspheres showed a similar ropivacaine release rate. We basically proved that the architecture of PCL has a negligible effect on ropivacaine release. Cell proliferation test revealed that the release of products from the microspheres resulted in insignificant toxicity towards mammalian cells.http://dx.doi.org/10.1155/2019/1412737 |
| spellingShingle | Wei Xiong Yue-kun Shen Peng Dong Ying Xiao Xiong-qing Huang Wen-qi Huang Lu Yang Xia Feng Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres International Journal of Polymer Science |
| title | Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres |
| title_full | Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres |
| title_fullStr | Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres |
| title_full_unstemmed | Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres |
| title_short | Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres |
| title_sort | controlled release of ropivacaine from single armed 1 pcl and four armed pcl 4 pcl microspheres |
| url | http://dx.doi.org/10.1155/2019/1412737 |
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