Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis
Background. There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patien...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/618269 |
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| author | Tarek Mahmoud Elghandour Sahar El Sayed Youssef Dalia Gamal Aly Mohamed Said Abd Elhameed Mehrevan Mostafa Abdel Moneim |
| author_facet | Tarek Mahmoud Elghandour Sahar El Sayed Youssef Dalia Gamal Aly Mohamed Said Abd Elhameed Mehrevan Mostafa Abdel Moneim |
| author_sort | Tarek Mahmoud Elghandour |
| collection | DOAJ |
| description | Background. There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. Methods. Thirty patients with severe plaque psoriasis were included: 15 patients received NB-UVB three times weekly (group I) and 15 patients received MTX 0.3 mg/kg per week (group II), both for 8 weeks. Before and after treatment, serum levels of IL-17 and IL-23 were investigated by ELISA technique and psoriasis area and severity index (PASI) was calculated. Results. After treatment, all patients showed a reduction in their PASI score, IL-17 and IL-23
serum levels with a nonsignificant difference between both therapeutic modalities (P value >0.05). A positive correlation was detected between the percent of reduction of IL-17, IL-23 and the percent of reduction of PASI score for patients receiving both treatments. No
correlation was found between the percent of reduction of IL-17, IL-23 and duration of disease or age of all patients in this study. Conclusion. Interleukin-17 and IL-23 serum level may serve as a potential biomarker for predicting the prognosis and therapeutic response of NB-UVB or MTX in treating psoriasis. |
| format | Article |
| id | doaj-art-ffb0bbec43d540dabcfb67a0dfbcb8e3 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-ffb0bbec43d540dabcfb67a0dfbcb8e32025-02-03T01:10:42ZengWileyDermatology Research and Practice1687-61051687-61132013-01-01201310.1155/2013/618269618269Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe PsoriasisTarek Mahmoud Elghandour0Sahar El Sayed Youssef1Dalia Gamal Aly2Mohamed Said Abd Elhameed3Mehrevan Mostafa Abdel Moneim4Department of Dermatology, Venereology, and Andrology, Ain Shams University, Abassya Square, Cairo 11566, EgyptDepartment of Dermatology, Venereology, and Andrology, Ain Shams University, Abassya Square, Cairo 11566, EgyptDepartment of Dermatology and Venereology, National Research Center, El-Bhoos Street, Dokki, Giza 12622, EgyptDepartment of Dermatology and Venereology, National Research Center, El-Bhoos Street, Dokki, Giza 12622, EgyptDepartment of Medical Biochemistry, National Research Center, El-Bhoos Street, Dokki, Giza 12622, EgyptBackground. There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. Methods. Thirty patients with severe plaque psoriasis were included: 15 patients received NB-UVB three times weekly (group I) and 15 patients received MTX 0.3 mg/kg per week (group II), both for 8 weeks. Before and after treatment, serum levels of IL-17 and IL-23 were investigated by ELISA technique and psoriasis area and severity index (PASI) was calculated. Results. After treatment, all patients showed a reduction in their PASI score, IL-17 and IL-23 serum levels with a nonsignificant difference between both therapeutic modalities (P value >0.05). A positive correlation was detected between the percent of reduction of IL-17, IL-23 and the percent of reduction of PASI score for patients receiving both treatments. No correlation was found between the percent of reduction of IL-17, IL-23 and duration of disease or age of all patients in this study. Conclusion. Interleukin-17 and IL-23 serum level may serve as a potential biomarker for predicting the prognosis and therapeutic response of NB-UVB or MTX in treating psoriasis.http://dx.doi.org/10.1155/2013/618269 |
| spellingShingle | Tarek Mahmoud Elghandour Sahar El Sayed Youssef Dalia Gamal Aly Mohamed Said Abd Elhameed Mehrevan Mostafa Abdel Moneim Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis Dermatology Research and Practice |
| title | Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis |
| title_full | Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis |
| title_fullStr | Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis |
| title_full_unstemmed | Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis |
| title_short | Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis |
| title_sort | effect of narrow band ultraviolet b therapy versus methotrexate on serum levels of interleukin 17 and interleukin 23 in egyptian patients with severe psoriasis |
| url | http://dx.doi.org/10.1155/2013/618269 |
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