Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology
Clinical and molecular similarities between canine mammary tumors (CMTs) and human breast cancer (HBC) propel scientists to further study their application in comparative oncology as a model for human breast cancer. In total, 64 canine mammary tumors were selected to study the most common markers, w...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2024/9319651 |
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| _version_ | 1832553097090564096 |
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| author | Amirhossein Razavirad Sanaz Rismanchi Pejman Mortazavi Ahad Muhammadnejad |
| author_facet | Amirhossein Razavirad Sanaz Rismanchi Pejman Mortazavi Ahad Muhammadnejad |
| author_sort | Amirhossein Razavirad |
| collection | DOAJ |
| description | Clinical and molecular similarities between canine mammary tumors (CMTs) and human breast cancer (HBC) propel scientists to further study their application in comparative oncology as a model for human breast cancer. In total, 64 canine mammary tumors were selected to study the most common markers, which are applicable for human breast cancer treatment, including estrogen and progesterone receptors (ER and PR), human epidermal growth factor (HER2/neu), Ki67, and cyclooxygenase 2 (Cox2). Immunohistochemistry (IHC) was used to assess the protein expression. The Veterinary Nottingham Prognostic Index (Vet-NPI) was also computed. Moreover, univariate and multivariable Cox proportional hazard analyses were applied to estimate hazard ratios (HRs). The results demonstrated that Ki67 was strongly expressed in the triple-negative tumors, and Ki67 protein expression continuously increased over the increase of Cox2 protein expression (p<0.001). Further analysis revealed a significant difference among canine mammary subtypes and Vet-NPI, in which triple-negative tumors displayed the highest mean score compared to other subtypes (p<0.001). In addition, the multivariable analysis revealed that the regional mastectomy procedure (adjusted HR = 2.78 (1.14–6.8)), the triple-negative tumors (adjusted HR = 48.08 (7.74–298.8)), strong Ki67 protein expression group (adjusted HR = 7.88 (2.02–30.68)), and strong Cox2 protein expression group (adjusted HR = 29.35 (5.18–166.4)) demonstrated significantly lower disease-free survival rates compared to other corresponding groups. Overall, canine mammary tumors showed strong similarities to human breast cancer in terms of clinical and molecular aspects; therefore, they could be suggested as a model for human breast cancer in comparative oncology. |
| format | Article |
| id | doaj-art-ffaf175ba4a4411fbd2961418f223e70 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-ffaf175ba4a4411fbd2961418f223e702025-02-03T05:56:55ZengWileyVeterinary Medicine International2042-00482024-01-01202410.1155/2024/9319651Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative OncologyAmirhossein Razavirad0Sanaz Rismanchi1Pejman Mortazavi2Ahad Muhammadnejad3Cancer Biology Research CenterCancer Biology Research CenterDepartment of PathobiologyCancer Biology Research CenterClinical and molecular similarities between canine mammary tumors (CMTs) and human breast cancer (HBC) propel scientists to further study their application in comparative oncology as a model for human breast cancer. In total, 64 canine mammary tumors were selected to study the most common markers, which are applicable for human breast cancer treatment, including estrogen and progesterone receptors (ER and PR), human epidermal growth factor (HER2/neu), Ki67, and cyclooxygenase 2 (Cox2). Immunohistochemistry (IHC) was used to assess the protein expression. The Veterinary Nottingham Prognostic Index (Vet-NPI) was also computed. Moreover, univariate and multivariable Cox proportional hazard analyses were applied to estimate hazard ratios (HRs). The results demonstrated that Ki67 was strongly expressed in the triple-negative tumors, and Ki67 protein expression continuously increased over the increase of Cox2 protein expression (p<0.001). Further analysis revealed a significant difference among canine mammary subtypes and Vet-NPI, in which triple-negative tumors displayed the highest mean score compared to other subtypes (p<0.001). In addition, the multivariable analysis revealed that the regional mastectomy procedure (adjusted HR = 2.78 (1.14–6.8)), the triple-negative tumors (adjusted HR = 48.08 (7.74–298.8)), strong Ki67 protein expression group (adjusted HR = 7.88 (2.02–30.68)), and strong Cox2 protein expression group (adjusted HR = 29.35 (5.18–166.4)) demonstrated significantly lower disease-free survival rates compared to other corresponding groups. Overall, canine mammary tumors showed strong similarities to human breast cancer in terms of clinical and molecular aspects; therefore, they could be suggested as a model for human breast cancer in comparative oncology.http://dx.doi.org/10.1155/2024/9319651 |
| spellingShingle | Amirhossein Razavirad Sanaz Rismanchi Pejman Mortazavi Ahad Muhammadnejad Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology Veterinary Medicine International |
| title | Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology |
| title_full | Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology |
| title_fullStr | Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology |
| title_full_unstemmed | Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology |
| title_short | Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology |
| title_sort | canine mammary tumors as a potential model for human breast cancer in comparative oncology |
| url | http://dx.doi.org/10.1155/2024/9319651 |
| work_keys_str_mv | AT amirhosseinrazavirad caninemammarytumorsasapotentialmodelforhumanbreastcancerincomparativeoncology AT sanazrismanchi caninemammarytumorsasapotentialmodelforhumanbreastcancerincomparativeoncology AT pejmanmortazavi caninemammarytumorsasapotentialmodelforhumanbreastcancerincomparativeoncology AT ahadmuhammadnejad caninemammarytumorsasapotentialmodelforhumanbreastcancerincomparativeoncology |