Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer
Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. Here, we review the roles of major...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2014/205796 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563332539744256 |
|---|---|
| author | Rizwan Romee Jeffrey W. Leong Todd A. Fehniger |
| author_facet | Rizwan Romee Jeffrey W. Leong Todd A. Fehniger |
| author_sort | Rizwan Romee |
| collection | DOAJ |
| description | Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. Here, we review the roles of major cytokines that regulate human NK cell development, survival, and function, including IL-2, IL-12, IL-15, IL-18, and IL-21, and their translation to the clinic as immunotherapy agents. We highlight a recent development in NK cell biology, the identification of innate NK cell memory, and focus on cytokine-induced memory-like (CIML) NK cells that result from a brief, combined activation with IL-12, IL-15, and IL-18. This activation results in long lived NK cells that exhibit enhanced functionality when they encounter a secondary stimulation and provides a new approach to enable NK cells for enhanced responsiveness to infection and cancer. An improved understanding of the cellular and molecular aspects of cytokine-cytokine receptor signals has led to a resurgence of interest in the clinical use of cytokines that sustain and/or activate NK cell antitumor potential. In the future, such strategies will be combined with negative regulatory signal blockade and enhanced recognition to comprehensively enhance NK cells for immunotherapy. |
| format | Article |
| id | doaj-art-ff9f9dd0b1e242819798dbd0dc77da88 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-ff9f9dd0b1e242819798dbd0dc77da882025-02-03T01:20:28ZengWileyScientifica2090-908X2014-01-01201410.1155/2014/205796205796Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of CancerRizwan Romee0Jeffrey W. Leong1Todd A. Fehniger2Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USANatural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. Here, we review the roles of major cytokines that regulate human NK cell development, survival, and function, including IL-2, IL-12, IL-15, IL-18, and IL-21, and their translation to the clinic as immunotherapy agents. We highlight a recent development in NK cell biology, the identification of innate NK cell memory, and focus on cytokine-induced memory-like (CIML) NK cells that result from a brief, combined activation with IL-12, IL-15, and IL-18. This activation results in long lived NK cells that exhibit enhanced functionality when they encounter a secondary stimulation and provides a new approach to enable NK cells for enhanced responsiveness to infection and cancer. An improved understanding of the cellular and molecular aspects of cytokine-cytokine receptor signals has led to a resurgence of interest in the clinical use of cytokines that sustain and/or activate NK cell antitumor potential. In the future, such strategies will be combined with negative regulatory signal blockade and enhanced recognition to comprehensively enhance NK cells for immunotherapy.http://dx.doi.org/10.1155/2014/205796 |
| spellingShingle | Rizwan Romee Jeffrey W. Leong Todd A. Fehniger Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer Scientifica |
| title | Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer |
| title_full | Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer |
| title_fullStr | Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer |
| title_full_unstemmed | Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer |
| title_short | Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer |
| title_sort | utilizing cytokines to function enable human nk cells for the immunotherapy of cancer |
| url | http://dx.doi.org/10.1155/2014/205796 |
| work_keys_str_mv | AT rizwanromee utilizingcytokinestofunctionenablehumannkcellsfortheimmunotherapyofcancer AT jeffreywleong utilizingcytokinestofunctionenablehumannkcellsfortheimmunotherapyofcancer AT toddafehniger utilizingcytokinestofunctionenablehumannkcellsfortheimmunotherapyofcancer |