Paving the path for invasion: The polyedric role of LASP1 in cancer
Although usually referred to as a structural actin-binding protein, LIM and SH3 domain-containing protein may actually be dynamically involved in the control of a wide spectrum of cellular processes, by virtue of its interaction with several molecular partners. Alongside being ubiquitously expressed...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705757 |
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| author | Vitalba Ruggieri Francesca Agriesti Tiziana Tataranni Roberto Perris Domenica Mangieri |
| author_facet | Vitalba Ruggieri Francesca Agriesti Tiziana Tataranni Roberto Perris Domenica Mangieri |
| author_sort | Vitalba Ruggieri |
| collection | DOAJ |
| description | Although usually referred to as a structural actin-binding protein, LIM and SH3 domain-containing protein may actually be dynamically involved in the control of a wide spectrum of cellular processes, by virtue of its interaction with several molecular partners. Alongside being ubiquitously expressed in physiological conditions, LIM and SH3 domain-containing protein is overexpressed in a growing number of human cancers, in which it may actively contribute to their aggressiveness by promoting cell proliferation and migration. In view of the recent findings, implicating the protein in cancer progression, we discuss here the most relevant discoveries highlighting the role of this versatile protein in various human tumors. The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker. This may be decisive not only to optimize existing pharmacological regimes but also to delineate novel, more efficacious therapeutic and/or preventive approaches. |
| format | Article |
| id | doaj-art-ff8b66c8caf94e5ab15a1190dcafe378 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-ff8b66c8caf94e5ab15a1190dcafe3782025-08-20T02:49:49ZengSAGE PublishingTumor Biology1423-03802017-05-013910.1177/1010428317705757Paving the path for invasion: The polyedric role of LASP1 in cancerVitalba Ruggieri0Francesca Agriesti1Tiziana Tataranni2Roberto Perris3Domenica Mangieri4Laboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), ItalyLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), ItalyLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), ItalyCenter for Molecular and Translational Oncology, University of Parma, Parma, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, Foggia, ItalyAlthough usually referred to as a structural actin-binding protein, LIM and SH3 domain-containing protein may actually be dynamically involved in the control of a wide spectrum of cellular processes, by virtue of its interaction with several molecular partners. Alongside being ubiquitously expressed in physiological conditions, LIM and SH3 domain-containing protein is overexpressed in a growing number of human cancers, in which it may actively contribute to their aggressiveness by promoting cell proliferation and migration. In view of the recent findings, implicating the protein in cancer progression, we discuss here the most relevant discoveries highlighting the role of this versatile protein in various human tumors. The correlation between LIM and SH3 domain-containing protein expression levels in cancer and the poor outcome and metastatic behavior of tumors denotes the clinical significance of this protein and hints its potential value as a new cancer prognostic or even diagnostic biomarker. This may be decisive not only to optimize existing pharmacological regimes but also to delineate novel, more efficacious therapeutic and/or preventive approaches.https://doi.org/10.1177/1010428317705757 |
| spellingShingle | Vitalba Ruggieri Francesca Agriesti Tiziana Tataranni Roberto Perris Domenica Mangieri Paving the path for invasion: The polyedric role of LASP1 in cancer Tumor Biology |
| title | Paving the path for invasion: The polyedric role of LASP1 in cancer |
| title_full | Paving the path for invasion: The polyedric role of LASP1 in cancer |
| title_fullStr | Paving the path for invasion: The polyedric role of LASP1 in cancer |
| title_full_unstemmed | Paving the path for invasion: The polyedric role of LASP1 in cancer |
| title_short | Paving the path for invasion: The polyedric role of LASP1 in cancer |
| title_sort | paving the path for invasion the polyedric role of lasp1 in cancer |
| url | https://doi.org/10.1177/1010428317705757 |
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