Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents
A new series of aryl derivatives of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles 11a–j were synthesised and their structures were characterized by analytical techniques. Further, the biological applications of the newly prepared compounds 11a–j were evaluated against four human cancer cell lines...
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006349 |
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| author | Divya Komirishetti Vasantha Mittapelli |
| author_facet | Divya Komirishetti Vasantha Mittapelli |
| author_sort | Divya Komirishetti |
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| description | A new series of aryl derivatives of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles 11a–j were synthesised and their structures were characterized by analytical techniques. Further, the biological applications of the newly prepared compounds 11a–j were evaluated against four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780), using the standard MTT assay, with etoposide as the positive control. The obtained results showed that most of the tested compounds displayed more potent activity with IC50 values range from 0.01 ± 0.098 µM to 8.12 ± 5.69 µM, whereas the positive control showed IC50 values ranging from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM. Among them, five compounds 11a, 11b, 11c, 11d and 11e possessed more potent activity. In which, one compound 11a, showed superior anticancer activity. |
| format | Article |
| id | doaj-art-ff88c993a9ef458cb9b6c2def1b29652 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Results in Chemistry |
| spelling | doaj-art-ff88c993a9ef458cb9b6c2def1b296522025-01-29T05:00:37ZengElsevierResults in Chemistry2211-71562025-01-0113101938Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agentsDivya Komirishetti0Vasantha Mittapelli1Department of Chemistry, University College of Science, Mahatma Gandhi University, Nalgonda 508254, Telangana, IndiaCorresponding author.; Department of Chemistry, University College of Science, Mahatma Gandhi University, Nalgonda 508254, Telangana, IndiaA new series of aryl derivatives of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles 11a–j were synthesised and their structures were characterized by analytical techniques. Further, the biological applications of the newly prepared compounds 11a–j were evaluated against four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780), using the standard MTT assay, with etoposide as the positive control. The obtained results showed that most of the tested compounds displayed more potent activity with IC50 values range from 0.01 ± 0.098 µM to 8.12 ± 5.69 µM, whereas the positive control showed IC50 values ranging from 0.17 ± 0.034 µM to 3.34 ± 0.152 µM. Among them, five compounds 11a, 11b, 11c, 11d and 11e possessed more potent activity. In which, one compound 11a, showed superior anticancer activity.http://www.sciencedirect.com/science/article/pii/S2211715624006349Suzuki-couplingImidazoleOxazolePyrimidineAnticancer activity |
| spellingShingle | Divya Komirishetti Vasantha Mittapelli Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents Results in Chemistry Suzuki-coupling Imidazole Oxazole Pyrimidine Anticancer activity |
| title | Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents |
| title_full | Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents |
| title_fullStr | Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents |
| title_full_unstemmed | Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents |
| title_short | Synthesis and biological evaluation of 4-(1H-imidazol-2-yl)-2-(pyrimidin-5-yl)oxazoles as potent anticancer agents |
| title_sort | synthesis and biological evaluation of 4 1h imidazol 2 yl 2 pyrimidin 5 yl oxazoles as potent anticancer agents |
| topic | Suzuki-coupling Imidazole Oxazole Pyrimidine Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006349 |
| work_keys_str_mv | AT divyakomirishetti synthesisandbiologicalevaluationof41himidazol2yl2pyrimidin5yloxazolesaspotentanticanceragents AT vasanthamittapelli synthesisandbiologicalevaluationof41himidazol2yl2pyrimidin5yloxazolesaspotentanticanceragents |