A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease
As the COVID-19 pandemic continues, there is an urgent need to identify clinical and laboratory predictors of disease severity and prognosis. Once the coronavirus enters the cell, it triggers additional events via different signaling pathways. Cellular and molecular deregulation evoked by coronaviru...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/9006487 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567559959871488 |
|---|---|
| author | Keynaz Keykavousi Fahimeh Nourbakhsh Nooshin Abdollahpour Farzaneh Fazeli Alireza Sedaghat Vahid Soheili Amirhossein Sahebkar |
| author_facet | Keynaz Keykavousi Fahimeh Nourbakhsh Nooshin Abdollahpour Farzaneh Fazeli Alireza Sedaghat Vahid Soheili Amirhossein Sahebkar |
| author_sort | Keynaz Keykavousi |
| collection | DOAJ |
| description | As the COVID-19 pandemic continues, there is an urgent need to identify clinical and laboratory predictors of disease severity and prognosis. Once the coronavirus enters the cell, it triggers additional events via different signaling pathways. Cellular and molecular deregulation evoked by coronavirus infection can manifest as changes in laboratory findings. Understanding the relationship between laboratory biomarkers and COVID-19 outcomes would help in developing a risk-stratified approach to the treatment of patients with this disease. The purpose of this review is to investigate the role of hematological (white blood cell (WBC), lymphocyte, and neutrophil count, neutrophil-to-lymphocyte ratio (NLR), platelet, and red blood cell (RBC) count), inflammatory (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and lactate dehydrogenase (LDH)), and biochemical (Albumin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, D-dimer, total Cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)) biomarkers in the pathogenesis of COVID-19 disease and how their levels vary according to disease severity. |
| format | Article |
| id | doaj-art-ff7b82791d8746ff893e6512b3a0820d |
| institution | Kabale University |
| issn | 1687-8779 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-ff7b82791d8746ff893e6512b3a0820d2025-02-03T01:01:20ZengWileyInternational Journal of Analytical Chemistry1687-87792022-01-01202210.1155/2022/9006487A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 DiseaseKeynaz Keykavousi0Fahimeh Nourbakhsh1Nooshin Abdollahpour2Farzaneh Fazeli3Alireza Sedaghat4Vahid Soheili5Amirhossein Sahebkar6Department of Pharmaceutical ControlMedical Toxicology Research CentreDepartment of BiologyDepartment of AnesthesiologyLung Diseases Research CenterDepartment of Pharmaceutical ControlApplied Biomedical Research CenterAs the COVID-19 pandemic continues, there is an urgent need to identify clinical and laboratory predictors of disease severity and prognosis. Once the coronavirus enters the cell, it triggers additional events via different signaling pathways. Cellular and molecular deregulation evoked by coronavirus infection can manifest as changes in laboratory findings. Understanding the relationship between laboratory biomarkers and COVID-19 outcomes would help in developing a risk-stratified approach to the treatment of patients with this disease. The purpose of this review is to investigate the role of hematological (white blood cell (WBC), lymphocyte, and neutrophil count, neutrophil-to-lymphocyte ratio (NLR), platelet, and red blood cell (RBC) count), inflammatory (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and lactate dehydrogenase (LDH)), and biochemical (Albumin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, D-dimer, total Cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)) biomarkers in the pathogenesis of COVID-19 disease and how their levels vary according to disease severity.http://dx.doi.org/10.1155/2022/9006487 |
| spellingShingle | Keynaz Keykavousi Fahimeh Nourbakhsh Nooshin Abdollahpour Farzaneh Fazeli Alireza Sedaghat Vahid Soheili Amirhossein Sahebkar A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease International Journal of Analytical Chemistry |
| title | A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease |
| title_full | A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease |
| title_fullStr | A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease |
| title_full_unstemmed | A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease |
| title_short | A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease |
| title_sort | review of routine laboratory biomarkers for the detection of severe covid 19 disease |
| url | http://dx.doi.org/10.1155/2022/9006487 |
| work_keys_str_mv | AT keynazkeykavousi areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT fahimehnourbakhsh areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT nooshinabdollahpour areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT farzanehfazeli areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT alirezasedaghat areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT vahidsoheili areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT amirhosseinsahebkar areviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT keynazkeykavousi reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT fahimehnourbakhsh reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT nooshinabdollahpour reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT farzanehfazeli reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT alirezasedaghat reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT vahidsoheili reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease AT amirhosseinsahebkar reviewofroutinelaboratorybiomarkersforthedetectionofseverecovid19disease |