LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation

LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation

Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and a major public health challenge. Lipid metabolism plays a crucial role in the metabolic reprogramming observed in HCC, although the underlying mechanisms are still being elucidated. Nile red staining and lipid...

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Main Authors: Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Deming Zhu, Wenhu Zhao, Chao Xu, Xiangyu Ling, Qingpeng Lv, Xiaoming Ai, Lianbao Kong, Wenzhou Ding
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
LRP11
Hepatocellular carcinoma
Deubiquitination
Lipid metabolism
Online Access:https://doi.org/10.1186/s10020-025-01097-6
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https://doi.org/10.1186/s10020-025-01097-6

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