Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation

Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation

Abstract Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that has an immunosuppressive effect mediated by binding to immune inhibitory leukocyte immunoglobulin-like receptors (LILR) B1 and LILRB2. A conventional HLA-G isoform, HLA-G1, forms a heterotrimeric complex composed of...

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Bibliographic Details
Main Authors: Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
HLA-G2
LILR
PEGylation
Immune checkpoint
Immunosuppressive
Online Access:https://doi.org/10.1038/s41598-024-85072-x
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