Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis

Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis

Abstract ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading to a mutation of G: C to T: A during DNA replication. 8-Oxoguanine DNA glycosylase...

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Bibliographic Details
Main Authors: Jing Wang, Chunshuang Li, Jinling Han, Yaoyao Xue, Xu Zheng, Ruoxi Wang, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Biomedical Science
Subjects:
8-oxoguanine
OGG1
Epigenetic regulation
Gene expression
Tumorigenesis
Online Access:https://doi.org/10.1186/s12929-024-01093-8
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