Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension
Objective. Essential hypertension is associated with reduced pain sensitivity of unclear aetiology. This study explores this issue using the Cold Pressor Test (CPT), a reliable pain/stress model, comparing CPT-related EEG activity in first episode hypertensives and controls. Method. 22 untreated hyp...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2017/7247514 |
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| author | Christos Papageorgiou Efstathios Manios Eleftheria Tsaltas Eleni Koroboki Maria Alevizaki Elias Angelopoulos Meletios-Athanasios Dimopoulos Charalabos Papageorgiou Nikolaos Zakopoulos |
| author_facet | Christos Papageorgiou Efstathios Manios Eleftheria Tsaltas Eleni Koroboki Maria Alevizaki Elias Angelopoulos Meletios-Athanasios Dimopoulos Charalabos Papageorgiou Nikolaos Zakopoulos |
| author_sort | Christos Papageorgiou |
| collection | DOAJ |
| description | Objective. Essential hypertension is associated with reduced pain sensitivity of unclear aetiology. This study explores this issue using the Cold Pressor Test (CPT), a reliable pain/stress model, comparing CPT-related EEG activity in first episode hypertensives and controls. Method. 22 untreated hypertensives and 18 matched normotensives underwent 24-hour ambulatory blood pressure monitoring (ABPM). EEG recordings were taken before, during, and after CPT exposure. Results. Significant group differences in CPT-induced EEG oscillations were covaried with the most robust cardiovascular differentiators by means of a Canonical Analysis. Positive correlations were noted between ABPM variables and Delta (1–4 Hz) oscillations during the tolerance phase; in high-alpha (10–12 Hz) oscillations during the stress unit and posttest phase; and in low-alpha (8–10 Hz) oscillations during CPT phases overall. Negative correlations were found between ABPM variables and Beta2 oscillations (16.5–20 Hz) during the posttest phase and Gamma (28.5–45 Hz) oscillations during the CPT phases overall. These relationships were localised at several sites across the cerebral hemispheres with predominance in the right hemisphere and left frontal lobe. Conclusions. These findings provide a starting point for increasing our understanding of the complex relationships between cerebral activation and cardiovascular functioning involved in regulating blood pressure changes. |
| format | Article |
| id | doaj-art-ff3f620abea34cc19ffa02f19ae9a4a9 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-ff3f620abea34cc19ffa02f19ae9a4a92025-02-03T01:07:20ZengWileyInternational Journal of Hypertension2090-03842090-03922017-01-01201710.1155/2017/72475147247514Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential HypertensionChristos Papageorgiou0Efstathios Manios1Eleftheria Tsaltas2Eleni Koroboki3Maria Alevizaki4Elias Angelopoulos5Meletios-Athanasios Dimopoulos6Charalabos Papageorgiou7Nikolaos Zakopoulos8Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece1st Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, “Eginition” Hospital, 115 28 Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece1st Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, “Eginition” Hospital, 115 28 Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece1st Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, “Eginition” Hospital, 115 28 Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, GreeceObjective. Essential hypertension is associated with reduced pain sensitivity of unclear aetiology. This study explores this issue using the Cold Pressor Test (CPT), a reliable pain/stress model, comparing CPT-related EEG activity in first episode hypertensives and controls. Method. 22 untreated hypertensives and 18 matched normotensives underwent 24-hour ambulatory blood pressure monitoring (ABPM). EEG recordings were taken before, during, and after CPT exposure. Results. Significant group differences in CPT-induced EEG oscillations were covaried with the most robust cardiovascular differentiators by means of a Canonical Analysis. Positive correlations were noted between ABPM variables and Delta (1–4 Hz) oscillations during the tolerance phase; in high-alpha (10–12 Hz) oscillations during the stress unit and posttest phase; and in low-alpha (8–10 Hz) oscillations during CPT phases overall. Negative correlations were found between ABPM variables and Beta2 oscillations (16.5–20 Hz) during the posttest phase and Gamma (28.5–45 Hz) oscillations during the CPT phases overall. These relationships were localised at several sites across the cerebral hemispheres with predominance in the right hemisphere and left frontal lobe. Conclusions. These findings provide a starting point for increasing our understanding of the complex relationships between cerebral activation and cardiovascular functioning involved in regulating blood pressure changes.http://dx.doi.org/10.1155/2017/7247514 |
| spellingShingle | Christos Papageorgiou Efstathios Manios Eleftheria Tsaltas Eleni Koroboki Maria Alevizaki Elias Angelopoulos Meletios-Athanasios Dimopoulos Charalabos Papageorgiou Nikolaos Zakopoulos Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension International Journal of Hypertension |
| title | Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension |
| title_full | Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension |
| title_fullStr | Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension |
| title_full_unstemmed | Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension |
| title_short | Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension |
| title_sort | brain oscillations elicited by the cold pressor test a putative index of untreated essential hypertension |
| url | http://dx.doi.org/10.1155/2017/7247514 |
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