Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy?
ABSTRACT We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux‐en‐Y gastric bypass (RYGB), wher...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14325 |
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| author | Yukako Yamamoto Osamu Sekine Jun Ito‐Kobayashi Ayane Nishida Takeshi Togawa Yuki Ozamoto Yasumitsu Oe Akeo Hagiwara Masaki Kobayashi Tadahiro Kitamura Masanori Iwanishi Akira Shimatsu Atsunori Kashiwagi |
| author_facet | Yukako Yamamoto Osamu Sekine Jun Ito‐Kobayashi Ayane Nishida Takeshi Togawa Yuki Ozamoto Yasumitsu Oe Akeo Hagiwara Masaki Kobayashi Tadahiro Kitamura Masanori Iwanishi Akira Shimatsu Atsunori Kashiwagi |
| author_sort | Yukako Yamamoto |
| collection | DOAJ |
| description | ABSTRACT We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux‐en‐Y gastric bypass (RYGB), where passage failure of a solid food intake at the gastric angle portion disappeared after the revision surgery. Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post‐LSG. Although a marked increase in glucose‐induced glicentin secretion after RYGB surgery with increased insulin secretion, further studies are needed to confirm if the increased glicentin secretion after RYGB surgery is linked to stimulation of insulin secretion. |
| format | Article |
| id | doaj-art-ff36fd2fae7b45c981556b9b2bbcc8fd |
| institution | Kabale University |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-ff36fd2fae7b45c981556b9b2bbcc8fd2025-02-01T10:02:01ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-02-0116234334710.1111/jdi.14325Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy?Yukako Yamamoto0Osamu Sekine1Jun Ito‐Kobayashi2Ayane Nishida3Takeshi Togawa4Yuki Ozamoto5Yasumitsu Oe6Akeo Hagiwara7Masaki Kobayashi8Tadahiro Kitamura9Masanori Iwanishi10Akira Shimatsu11Atsunori Kashiwagi12Department of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanDepartment of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanDepartment of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanDepartment of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanDepartment of Bariatric and Metabolic Surgery Omi Medical Center Kusatsu Shiga JapanDepartment of Bariatric and Metabolic Surgery Omi Medical Center Kusatsu Shiga JapanDepartment of Bariatric and Metabolic Surgery Omi Medical Center Kusatsu Shiga JapanDepartment of Bariatric and Metabolic Surgery Omi Medical Center Kusatsu Shiga JapanMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation Gunma University Maebashi Gunma JapanMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation Gunma University Maebashi Gunma JapanDepartment of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanDepartment of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanDepartment of Diabetes and Endocrinology Omi Medical Center Kusatsu Shiga JapanABSTRACT We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux‐en‐Y gastric bypass (RYGB), where passage failure of a solid food intake at the gastric angle portion disappeared after the revision surgery. Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post‐LSG. Although a marked increase in glucose‐induced glicentin secretion after RYGB surgery with increased insulin secretion, further studies are needed to confirm if the increased glicentin secretion after RYGB surgery is linked to stimulation of insulin secretion.https://doi.org/10.1111/jdi.14325glicentinglycemic controlinsulin secretionmetabolic surgery |
| spellingShingle | Yukako Yamamoto Osamu Sekine Jun Ito‐Kobayashi Ayane Nishida Takeshi Togawa Yuki Ozamoto Yasumitsu Oe Akeo Hagiwara Masaki Kobayashi Tadahiro Kitamura Masanori Iwanishi Akira Shimatsu Atsunori Kashiwagi Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? Journal of Diabetes Investigation glicentin glycemic control insulin secretion metabolic surgery |
| title | Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? |
| title_full | Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? |
| title_fullStr | Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? |
| title_full_unstemmed | Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? |
| title_short | Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? |
| title_sort | is glucose induced hypersecretion of glicentin after the revision surgery using roux en y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy |
| topic | glicentin glycemic control insulin secretion metabolic surgery |
| url | https://doi.org/10.1111/jdi.14325 |
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