Pharmacological Blocking of Adiponectin Receptors Induces Alzheimer’s Disease-like Neuropathology and Impairs Hippocampal Function

Pharmacological Blocking of Adiponectin Receptors Induces Alzheimer’s Disease-like Neuropathology and Impairs Hippocampal Function

<b>Background/Objectives</b>: Previous studies have shown that adiponectin deficiency or blocking adiponectin receptors (AdipoRs) in the brain can lead to an Alzheimer’s disease (AD)-like neuropathology. While AdipoRs are abundantly expressed in peripheral tissues, the effects of blockin...

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Bibliographic Details
Main Authors: Hui-Hui Guo, Hai-Ning Ou, Jia-Sui Yu, Suk-Yu Yau, Hector Wing-Hong Tsang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
Subjects:
adiponectin
adiponectin receptor antagonist
cognitive impairment
tau
β-amyloid
Online Access:https://www.mdpi.com/2227-9059/13/5/1056
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