Dysregulated mTOR networks in experimental sporadic Alzheimer’s disease

BackgroundBeyond the signature amyloid-beta plaques and neurofibrillary tangles, Alzheimer’s disease (AD) has been shown to exhibit dysregulated metabolic signaling through insulin and insulin-like growth factor (IGF) networks that crosstalk with the mechanistic target of rapamycin (mTOR). Its broad...

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Bibliographic Details
Main Authors: Suzanne M. de la Monte, Ming Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Cellular Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1432359/full
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