Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis
Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-establishe...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/175941 |
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| author | Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse |
| author_facet | Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse |
| author_sort | Sumadhya Deepika Fernando |
| collection | DOAJ |
| description | Many trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis.
Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established microfilaricidal and some macrofilaricidal effects. Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. The role of albendazole (ALB) in treatment regimens is not well established though the drug has a microfilaricidal effect. The combination of DEC+ALB has a better long-term impact than IVM+ALB. Recent trials have shown that doxycycline therapy against Wolbachia, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level. |
| format | Article |
| id | doaj-art-ff0cf969ac304a49a8057d4400212dbe |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-ff0cf969ac304a49a8057d4400212dbe2025-02-03T05:58:29ZengWileyJournal of Tropical Medicine1687-96861687-96942011-01-01201110.1155/2011/175941175941Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian FilariasisSumadhya Deepika Fernando0Chaturaka Rodrigo1Senaka Rajapakse2Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo 08, Sri LankaUniversity Medical Unit, National Hospital of Sri Lanka, Colombo 08, Sri LankaDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo 08, Sri LankaMany trials have explored the efficacy of individual drugs and drug combinations to treat bancroftian filariasis. This narrative review summarizes the current evidence for drug management of bancroftian filariasis. Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established microfilaricidal and some macrofilaricidal effects. Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. The role of albendazole (ALB) in treatment regimens is not well established though the drug has a microfilaricidal effect. The combination of DEC+ALB has a better long-term impact than IVM+ALB. Recent trials have shown that doxycycline therapy against Wolbachia, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level.http://dx.doi.org/10.1155/2011/175941 |
| spellingShingle | Sumadhya Deepika Fernando Chaturaka Rodrigo Senaka Rajapakse Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis Journal of Tropical Medicine |
| title | Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
| title_full | Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
| title_fullStr | Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
| title_full_unstemmed | Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
| title_short | Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis |
| title_sort | current evidence on the use of antifilarial agents in the management of bancroftian filariasis |
| url | http://dx.doi.org/10.1155/2011/175941 |
| work_keys_str_mv | AT sumadhyadeepikafernando currentevidenceontheuseofantifilarialagentsinthemanagementofbancroftianfilariasis AT chaturakarodrigo currentevidenceontheuseofantifilarialagentsinthemanagementofbancroftianfilariasis AT senakarajapakse currentevidenceontheuseofantifilarialagentsinthemanagementofbancroftianfilariasis |