Exploring RPA1-ETAA1 axis via high-throughput data analysis: implications for PD-L1 nuclear translocation and tumor-immune dynamics in liver cancer

Exploring RPA1-ETAA1 axis via high-throughput data analysis: implications for PD-L1 nuclear translocation and tumor-immune dynamics in liver cancer

IntroductionETAA1 is recruited to DNA damage sites via its RPA -binding and ATR -activating domain (AAD) motifs, where RPA binding is crucial for ETAA1’s regulation of ATR activity. Methods & resultsOur findings associate Programmed Death- Ligand1 (PD-L1) with the RPA1-ETAA1 axis, suggesting...

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Bibliographic Details
Main Authors: Gaofeng Qin, Zengkuan Chen, Weihong Tian, Hongbo Chen, Yu Zhang, Wangzhi Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
replication protein A (RPA)
Ewing tumor-associated antigen 1 (ETAA1)
PD-L1
immune infiltration
liver cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1492531/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1492531/full

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