Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells

Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells

IntroductionPancreatic beta cells undergo metabolic remodeling in response to metabolic overload, but the functional significance of this remains unclear. 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is a glycolytic regulator that may play a role in beta cell adaptation under acute...

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Bibliographic Details
Main Authors: Koki Chiba, Hiroshi Nomoto, Rimi Izumihara, Xinxin Zhang, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
beta cells
diabetes
metabolic remodeling
glycolysis
PFKFB3
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1552700/full
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