The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts
Giant kelp (Macrocystis pyrifera) is a paramount species of immense ecological and economic importance. It forms dense underwater forests, providing crucial habitat and serving as a foundation species for diverse marine ecosystems. Understanding the genetics of giant kelp is essential for conservati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2024.1338572/full |
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| author | Jose Francisco Diesel Gary Molano Sergey V. Nuzhdin |
| author_facet | Jose Francisco Diesel Gary Molano Sergey V. Nuzhdin |
| author_sort | Jose Francisco Diesel |
| collection | DOAJ |
| description | Giant kelp (Macrocystis pyrifera) is a paramount species of immense ecological and economic importance. It forms dense underwater forests, providing crucial habitat and serving as a foundation species for diverse marine ecosystems. Understanding the genetics of giant kelp is essential for conservation and sustainable farming, safeguarding these valuable ecosystems and their benefits. By analyzing mutations based on their impact, we can gain insights into the potential functional consequences and implications for the organism, helping to identify critical genes or regions that may play a significant role in adaptation, development, and environmental response. To achieve this, we annotated the effects and impact of spontaneous mutations in 559 giant kelp individuals from four different populations. We found over 15.9 million mutations in genes of giant kelp, and classified them into modifier, low, moderate, and high impact depending on their predicted effects. The creation of this mutation effect database, attached to the seedbank of these individuals, offers several applications, including enhancing breeding programs, aiding genetic engineering with naturally occurring mutations, and developing strategies to mitigate the impact of environmental changes. |
| format | Article |
| id | doaj-art-fefd1d489df84247aa36f62044244a03 |
| institution | Kabale University |
| issn | 1664-462X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-fefd1d489df84247aa36f62044244a032025-01-27T06:40:57ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2025-01-011510.3389/fpls.2024.13385721338572The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockoutsJose Francisco DieselGary MolanoSergey V. NuzhdinGiant kelp (Macrocystis pyrifera) is a paramount species of immense ecological and economic importance. It forms dense underwater forests, providing crucial habitat and serving as a foundation species for diverse marine ecosystems. Understanding the genetics of giant kelp is essential for conservation and sustainable farming, safeguarding these valuable ecosystems and their benefits. By analyzing mutations based on their impact, we can gain insights into the potential functional consequences and implications for the organism, helping to identify critical genes or regions that may play a significant role in adaptation, development, and environmental response. To achieve this, we annotated the effects and impact of spontaneous mutations in 559 giant kelp individuals from four different populations. We found over 15.9 million mutations in genes of giant kelp, and classified them into modifier, low, moderate, and high impact depending on their predicted effects. The creation of this mutation effect database, attached to the seedbank of these individuals, offers several applications, including enhancing breeding programs, aiding genetic engineering with naturally occurring mutations, and developing strategies to mitigate the impact of environmental changes.https://www.frontiersin.org/articles/10.3389/fpls.2024.1338572/fullMacrocystis pyriferagiant kelpgeneticsmutationknockoutseedbank |
| spellingShingle | Jose Francisco Diesel Gary Molano Sergey V. Nuzhdin The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts Frontiers in Plant Science Macrocystis pyrifera giant kelp genetics mutation knockout seedbank |
| title | The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts |
| title_full | The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts |
| title_fullStr | The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts |
| title_full_unstemmed | The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts |
| title_short | The mutation atlas of giant kelp (Macrocystis pyrifera): a mutation database resource for natural knockouts |
| title_sort | mutation atlas of giant kelp macrocystis pyrifera a mutation database resource for natural knockouts |
| topic | Macrocystis pyrifera giant kelp genetics mutation knockout seedbank |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2024.1338572/full |
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