Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study
Objectives. This prospective, observational, multicentre study aims to identify electrodiagnostic (EDX) markers of clinical recovery in patients with traumatic neuropathy (TN) receiving surgical (S) and nonsurgical (NS) treatments. Methods. Subjects referred to the Italian Traumatic Neuropathy Netwo...
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Wiley
2016-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/4619631 |
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| author | Palma Ciaramitaro Mauro Mondelli Eugenia Rota Bruno Battiston Arman Sard Italo Pontini Giuliano Faccani Giuseppe Migliaretti Aristide Merola Dario Cocito Italian Network for Traumatic Neuropathies |
| author_facet | Palma Ciaramitaro Mauro Mondelli Eugenia Rota Bruno Battiston Arman Sard Italo Pontini Giuliano Faccani Giuseppe Migliaretti Aristide Merola Dario Cocito Italian Network for Traumatic Neuropathies |
| author_sort | Palma Ciaramitaro |
| collection | DOAJ |
| description | Objectives. This prospective, observational, multicentre study aims to identify electrodiagnostic (EDX) markers of clinical recovery in patients with traumatic neuropathy (TN) receiving surgical (S) and nonsurgical (NS) treatments. Methods. Subjects referred to the Italian Traumatic Neuropathy Network between 2010 and 2011 (307 patients, for a total of 444 TN) were evaluated with serial clinical/EDX evaluations at 6, 12, 24, and 36 months of follow-up. Results. Primary surgery was performed in 21 subjects with open lesions and evidence of neurotmesis, while closed lesions were treated with either conservative medical approach (216 patients) or secondary surgery (70 patients), according to the clinical spontaneous recovery at 4–6 months. Clinical improvement correlated with the increase of the compound muscle action potential amplitude (OR 3.76; CI 1.61–8.76), particularly in the S group (OR 7.25; CI 1.2–43.87), and with sensory nerve action potential amplitude in the NS group (OR 4.35; CI 1.14–16.69). No correlations were found with needle electromyography qualitative evaluations, changes in maximal voluntary recruitment, age, and gender. Conclusions. Nerve conduction studies (NCS) represent the more accurate neurophysiological markers of clinical outcome in patients with TN. Significance. Serial NCS assessments predict the functional recovery in TN, increasing the accuracy of peripheral nerves surgical decision-making process. |
| format | Article |
| id | doaj-art-fef21a5532fc4e008258c62512deb67d |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-fef21a5532fc4e008258c62512deb67d2025-02-03T05:51:52ZengWileyNeurology Research International2090-18522090-18602016-01-01201610.1155/2016/46196314619631Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective StudyPalma Ciaramitaro0Mauro Mondelli1Eugenia Rota2Bruno Battiston3Arman Sard4Italo Pontini5Giuliano Faccani6Giuseppe Migliaretti7Aristide Merola8Dario Cocito9Italian Network for Traumatic Neuropathies10EMG Service, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Torino, ItalyEMG Service, Azienda Sanitaria Locale 7 Siena, Siena, ItalyNeurology Division, Piacenza Hospital, Piacenza, ItalyTraumatology Division, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Torino, ItalyHand Surgery Division, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Torino, ItalyHand Surgery Division, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Torino, ItalyNeurosurgery Division, CTO Hospital, AOU Città della Salute e della Scienza di Torino, Torino, ItalyPublic Health and Microbiology Department, University of Torino, Torino, ItalyDepartment of Neurosciences, Molinette Hospital, Università degli Studi di Torino, Torino, ItalyAssociazione Polineuropatie Croniche Piemonte ONLUS, Torino, ItalyGdS Neuropatie Traumatiche e Iatrogene, SINC (Società Italiana di Neurofisiologia Clinica), Via Nizza 45, 00198 Roma, ItalyObjectives. This prospective, observational, multicentre study aims to identify electrodiagnostic (EDX) markers of clinical recovery in patients with traumatic neuropathy (TN) receiving surgical (S) and nonsurgical (NS) treatments. Methods. Subjects referred to the Italian Traumatic Neuropathy Network between 2010 and 2011 (307 patients, for a total of 444 TN) were evaluated with serial clinical/EDX evaluations at 6, 12, 24, and 36 months of follow-up. Results. Primary surgery was performed in 21 subjects with open lesions and evidence of neurotmesis, while closed lesions were treated with either conservative medical approach (216 patients) or secondary surgery (70 patients), according to the clinical spontaneous recovery at 4–6 months. Clinical improvement correlated with the increase of the compound muscle action potential amplitude (OR 3.76; CI 1.61–8.76), particularly in the S group (OR 7.25; CI 1.2–43.87), and with sensory nerve action potential amplitude in the NS group (OR 4.35; CI 1.14–16.69). No correlations were found with needle electromyography qualitative evaluations, changes in maximal voluntary recruitment, age, and gender. Conclusions. Nerve conduction studies (NCS) represent the more accurate neurophysiological markers of clinical outcome in patients with TN. Significance. Serial NCS assessments predict the functional recovery in TN, increasing the accuracy of peripheral nerves surgical decision-making process.http://dx.doi.org/10.1155/2016/4619631 |
| spellingShingle | Palma Ciaramitaro Mauro Mondelli Eugenia Rota Bruno Battiston Arman Sard Italo Pontini Giuliano Faccani Giuseppe Migliaretti Aristide Merola Dario Cocito Italian Network for Traumatic Neuropathies Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study Neurology Research International |
| title | Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study |
| title_full | Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study |
| title_fullStr | Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study |
| title_full_unstemmed | Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study |
| title_short | Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study |
| title_sort | electrophysiological predictors of clinical outcome in traumatic neuropathies a multicenter prospective study |
| url | http://dx.doi.org/10.1155/2016/4619631 |
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