A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch
Abstract Peripheral nerve damage can cause debilitating symptoms ranging from numbness and pain to sensory loss and atrophy. To uncover the underlying mechanisms of peripheral nerve injury, our research aims to develop a relationship between biomechanical peripheral nerve damage and function through...
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| Format: | Article |
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Wiley
2024-11-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70125 |
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| author | Nicholas C. Vasas Adam M. Forrest Nathaniel A. Myers Michael B. Christensen Jenny L. Pierce Sidney M. Kaufmann Kimberly B. Lanaghen Randal C. Paniello Julie M. Barkmeier‐Kraemer Jonathan P. Vande Geest |
| author_facet | Nicholas C. Vasas Adam M. Forrest Nathaniel A. Myers Michael B. Christensen Jenny L. Pierce Sidney M. Kaufmann Kimberly B. Lanaghen Randal C. Paniello Julie M. Barkmeier‐Kraemer Jonathan P. Vande Geest |
| author_sort | Nicholas C. Vasas |
| collection | DOAJ |
| description | Abstract Peripheral nerve damage can cause debilitating symptoms ranging from numbness and pain to sensory loss and atrophy. To uncover the underlying mechanisms of peripheral nerve injury, our research aims to develop a relationship between biomechanical peripheral nerve damage and function through finite element modeling. A noncontact, ex vivo electrophysiology chamber, capable of axially stretching explanted nerves while recording electrical signals, was used to investigate peripheral nerve injury. Successive stretch trials were run on eight sciatic nerves (four females and four males) excised from Sprague–Dawley rats. Nerves were stretched until 50% compound action potential (CAP) amplitude reduction was obtained. A constitutive model developed by Raghavan and Vorp was suitable for rat sciatic nerves, with an average α and β of 0.183 MPa and 1.88 MPa, respectively. We then generated 95% confidence intervals for the stretch at which specific CAP amplitude reductions would occur, which compares well to previous studies. We also developed a finite element model that can predict stretch‐induced signaling deficits, applicable for complex nerve geometries and injuries. This relationship between nerve biomechanics and function can be expanded upon to create a clinical model for peripheral nerve dysfunction due to stretch. |
| format | Article |
| id | doaj-art-feef243045fb48bab19d84f87b6a366f |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-feef243045fb48bab19d84f87b6a366f2025-01-25T06:41:00ZengWileyPhysiological Reports2051-817X2024-11-011221n/an/a10.14814/phy2.70125A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretchNicholas C. Vasas0Adam M. Forrest1Nathaniel A. Myers2Michael B. Christensen3Jenny L. Pierce4Sidney M. Kaufmann5Kimberly B. Lanaghen6Randal C. Paniello7Julie M. Barkmeier‐Kraemer8Jonathan P. Vande Geest9Department of Bioengineering, Swanson School of Engineering University of Pittsburgh Pittsburgh Pennsylvania USADepartment of Bioengineering, Swanson School of Engineering University of Pittsburgh Pittsburgh Pennsylvania USADepartment of Bioengineering, Swanson School of Engineering University of Pittsburgh Pittsburgh Pennsylvania USADepartment of Otolaryngology – Head & Neck Surgery University of Utah School of Medicine Salt Lake City Utah USADepartment of Otolaryngology – Head & Neck Surgery University of Utah School of Medicine Salt Lake City Utah USADepartment of Otolaryngology – Head & Neck Surgery University of Utah School of Medicine Salt Lake City Utah USADepartment of Otolaryngology – Head & Neck Surgery University of Utah School of Medicine Salt Lake City Utah USADepartment of Otolaryngology–Head and Neck Surgery Washington University School of Medicine St. Louis Missouri USADepartment of Otolaryngology – Head & Neck Surgery University of Utah School of Medicine Salt Lake City Utah USADepartment of Bioengineering, Swanson School of Engineering University of Pittsburgh Pittsburgh Pennsylvania USAAbstract Peripheral nerve damage can cause debilitating symptoms ranging from numbness and pain to sensory loss and atrophy. To uncover the underlying mechanisms of peripheral nerve injury, our research aims to develop a relationship between biomechanical peripheral nerve damage and function through finite element modeling. A noncontact, ex vivo electrophysiology chamber, capable of axially stretching explanted nerves while recording electrical signals, was used to investigate peripheral nerve injury. Successive stretch trials were run on eight sciatic nerves (four females and four males) excised from Sprague–Dawley rats. Nerves were stretched until 50% compound action potential (CAP) amplitude reduction was obtained. A constitutive model developed by Raghavan and Vorp was suitable for rat sciatic nerves, with an average α and β of 0.183 MPa and 1.88 MPa, respectively. We then generated 95% confidence intervals for the stretch at which specific CAP amplitude reductions would occur, which compares well to previous studies. We also developed a finite element model that can predict stretch‐induced signaling deficits, applicable for complex nerve geometries and injuries. This relationship between nerve biomechanics and function can be expanded upon to create a clinical model for peripheral nerve dysfunction due to stretch.https://doi.org/10.14814/phy2.70125cauchy stresscompound action potentialfinite element modelperipheral nerve damagestretch |
| spellingShingle | Nicholas C. Vasas Adam M. Forrest Nathaniel A. Myers Michael B. Christensen Jenny L. Pierce Sidney M. Kaufmann Kimberly B. Lanaghen Randal C. Paniello Julie M. Barkmeier‐Kraemer Jonathan P. Vande Geest A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch Physiological Reports cauchy stress compound action potential finite element model peripheral nerve damage stretch |
| title | A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch |
| title_full | A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch |
| title_fullStr | A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch |
| title_full_unstemmed | A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch |
| title_short | A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch |
| title_sort | finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch |
| topic | cauchy stress compound action potential finite element model peripheral nerve damage stretch |
| url | https://doi.org/10.14814/phy2.70125 |
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