Thyroid disorders as predictors of cemiplimab efficacy in recurrent/metastatic cervical cancer: real-world evidence from Poland

Thyroid disorders as predictors of cemiplimab efficacy in recurrent/metastatic cervical cancer: real-world evidence from Poland

IntroductionImmune checkpoint inhibitors have improved survival in patients with recurrent or metastatic cervical cancer (r/mCC), yet reliable predictors of treatment efficacy remain undefined. Immune-related adverse events (irAEs) have been suggested as potential predictors of response, but evidenc...

Full description

Saved in:

Bibliographic Details
Main Authors:	Renata Pacholczak-Madej, Maja Lisik-Habib, Radosław Mądry, Monika Szarszewska, Zuzanna Borysiewicz, Katarzyna Gabalewicz, Ewa Iwańska, Wiktor Szatkowski, Mirosława Puskulluoglu, Jerzy Jakubowicz, Paweł Blecharz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Immunology
Subjects:	cemiplimab uterine cervical neoplasms thyroid diseases immune checkpoint inhibitors immune-related adverse events
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604826/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cemiplimab and diabetic ketoacidosis: a case report of a rare endocrinopathy associated with immune checkpoint inhibitors
by: Anna Arecco, et al.
Published: (2025-03-01)

Cemiplimab monotherapy in Japanese patients with recurrent or metastatic cervical cancer
by: Kosei Hasegawa, et al.
Published: (2024-09-01)

Cemiplimab‐Induced Colitis Causing Hypovolemic Shock: A Case Report and Literature Review
by: Saeed S. Graham, et al.
Published: (2025-06-01)

Effectiveness and safety of nivolumab and ipilimumab in older adults with renal cell carcinoma: findings from a multicenter observational study in Poland
by: Artur Drobniak, et al.
Published: (2025-08-01)

Evaluation of Clinical Parameters Associated with Response and Resistance to Cemiplimab in Locally Advanced and Metastatic Cutaneous Squamous Cell Carcinoma: A Multi-Institutional Retrospective Cohort Study
by: Joseph Edward Haigh, et al.
Published: (2025-03-01)

Health‐related quality of life in patients with metastatic basal cell carcinoma treated with cemiplimab: Analysis of a phase 2 trial
by: Ketty Peris, et al.
Published: (2024-07-01)

Unveiling cutaneous adenosquamous carcinoma: A systematic review and case analysis of a rare cutaneous malignancy
by: Adam Christie, et al.
Published: (2025-01-01)

Use of Preoperative Immunotherapy in Locally Advanced Unresectable Cutaneous Squamous Cell Carcinoma: A Case Report
by: Sara Cerqueira Cabral, et al.
Published: (2024-10-01)

PD-1 monoclonal antibodies as an effective treatment for rare cutaneous malignancies: a case report
by: Ryan Falk, et al.
Published: (2025-06-01)

An exploration of the natural and acquired immunological mechanisms to high-risk human papillomavirus infection and unmasking immune escape in cervical cancer: A concise synopsis
by: Mohammed Mohsen Mohammed, et al.
Published: (2025-01-01)

Aggressive cutaneous squamous cell carcinoma in a patient on Janus-kinase inhibitor therapy
by: Ana M. Aragon Sierra, MD, et al.
Published: (2025-03-01)

NRAS tumor mutations are associated with reduced odds of dermatologic adverse events in patients with metastatic melanoma receiving immune checkpoint inhibitors
by: Michael S. Chang, MD, et al.
Published: (2025-02-01)

IMMUNE PARAMETERS OF THE PERITONEAL FLUID IN UTERINE MYOMA. PROGNOSTIC RELEVANCE
by: A. I. Malyshkina, et al.
Published: (2014-07-01)

Prevalence and prognostic value of the programmed cell death-ligand 1 (PD-L1) expression among tumor samples from cervical cancer patients
by: Michelle Marques Lessa, et al.
Published: (2022-10-01)

REPRESENTATION OF DIFFERENT LYMPHOCYTES' POPULATIONS IN PERIPHERAL BLOOD OF PATIENTS WITH UTERINE MYOMA
by: Ye. E. Zueva, et al.
Published: (2014-07-01)

Effects of in ovo stimulation with potential epigenetic modulators on immune system phenotype across three generations in a chicken model
by: Jan P. Madej, et al.
Published: (2025-07-01)

Conceptus signaling markers in immune cells enhance pregnancy prediction in beef cattle
by: Isabella Rio Feltrin, et al.
Published: (2025-05-01)

STATE OF HUMORAL IMMUNITY IN WOMEN WITH NEOPLASTIC DISEASES OF THE UTERUS
by: A. V. Efremov, et al.
Published: (2016-09-01)

Identification of an Immune Cell Infiltration-Related Prognostic Model to Guide Immunotherapy in Endometrial Carcinoma
by: Haijun Zhu, et al.
Published: (2023-10-01)

Early Ultrasound Signs of Splenomegaly in Neonates
by: S. A. Perepelitsa, et al.
Published: (2019-09-01)

MYB Proto-Oncogene Like 2 identified as a biomarker for uterine corpus endometrial carcinoma: evidence from bioinformatics and clinical validation
by: Jiaoyun Lu, et al.
Published: (2025-05-01)

Adrenal insufficiency induced by immune checkpoint inhibitors anticancer therapy
by: Paulina Ramaneckaite, et al.
Published: (2025-01-01)

Low density of intratumoral M1-macrophage infiltration may correlate with worse prognosis in low-grade early-stage uterine endometrioid carcinoma
by: Michiko Nagamine, et al.
Published: (2025-06-01)

Directions in Ornamental Herbaceous Plant Selection in the Central European Temperate Zone in the Time of Climate Change: Benefits and Threats
by: Marta Joanna Monder, et al.
Published: (2024-12-01)

Immunogenic cell death-related genes as prognostic biomarkers and therapeutic insights in uterine corpus endometrial carcinoma: an integrative bioinformatics analysis
by: Tianfei Yi, et al.
Published: (2025-07-01)

Key issues in the management of cervical cancer: consensus recommendations by a Brazilian expert panel
by: Eduardo Paulino, et al.
Published: (2023-04-01)

Distance Teaching as an Element of an Academic Course. Original Research Results
by: Małgorzata MADEJ, et al.
Published: (2015-05-01)

Cemiplimab Immunotherapy in the Treatment of Cutaneous Squamous Cell Carcinoma
by: Z. Kozéki, et al.
Published: (2024-01-01)

Expression and prognostic value of EGF-like domain multiple 6 in uterine corpus endometrial carcinoma and its correlation with immune cell infiltration
by: Qiannan Li, et al.
Published: (2025-07-01)

Uterine Artery Embolization for Iatrogenic Uterine Vascular Injuries
by: S. Vignesh, et al.
Published: (2024-12-01)

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma
by: Xiaoxuan Tang, et al.
Published: (2025-02-01)

The Effects of the COVID-19 Pandemic on Abnormal Uterine Bleeding According to the PALM-COEIN Classification
by: Onur Bektas, et al.
Published: (2024-12-01)

MORPHOLOGICAL CHANGES OF UTERINE TISSUES AFTER EMBOLIZATION OF UTERINE ARTERIES IN PATIENTS WITH LEIOMYOMA
by: G. P. Titova, et al.
Published: (2018-01-01)

The impact of GnRH agonists on endometrial immune cells in patients with adenomyosis: a prospective cohort study
by: Anna Lena Zippl, et al.
Published: (2025-06-01)

ENDOVASCULAR HEMOSTASIS IN UTERINE BLEEDING IN PATIENTS WITH UTERINE LEIOMYOMA
by: M. M. Damirov, et al.
Published: (2017-03-01)

Effectiveness of Bacterial Lysates as Immune-Boosting Supplements: Evaluating a Novel Approach to Immune Health
by: Gabriela Mąsior, et al.
Published: (2024-12-01)

The Influence of Friction Parameters and Material Type on Results in the Block-on-Ring Friction System
by: Marcin Madej, et al.
Published: (2025-02-01)

Editorial: Innate and adaptive immune responses to viral infection
by: Stefania Varchetta, et al.
Published: (2025-01-01)

MODERN APPROACHES TO THE PATHOGENESIS OF UTERINE LEIOMYOMA, COMPLICATED WITH UTERINE BLEEDING (A LITERATURE REVIEW)
by: M. M. Damirov
Published: (2016-03-01)

Uterine artery embolization versus hysterectomy for uterine myoma: a meta-analysis of postoperative ovarian function
by: Lin Li, et al.
Published: (2024-04-01)