Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
<b>Background</b>: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic kidney disease (CKD) in patients with type 2 diabetes mellitus with normal renal function remains...
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MDPI AG
2025-01-01
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| author | Yu-Ling Lin Sheng-Hsiang Lin Hsi-Hao Wang Wan-Chia Hsu Shih-Yuan Hung Yuan-Yow Chiou Hung-Hsiang Liou Min-Yu Chang Li-Chun Ho Ching-Fang Wu Yi-Che Lee |
| author_facet | Yu-Ling Lin Sheng-Hsiang Lin Hsi-Hao Wang Wan-Chia Hsu Shih-Yuan Hung Yuan-Yow Chiou Hung-Hsiang Liou Min-Yu Chang Li-Chun Ho Ching-Fang Wu Yi-Che Lee |
| author_sort | Yu-Ling Lin |
| collection | DOAJ |
| description | <b>Background</b>: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic kidney disease (CKD) in patients with type 2 diabetes mellitus with normal renal function remains unclear. Therefore, this study aimed to investigate whether metformin could prevent the development of new-onset CKD in such patients. <b>Methods</b>: This retrospective, observational, multicenter cohort study included 316,693 patients with type 2 diabetes mellitus. After matching using the inverse probability of treatment weighting, 9109 metformin users and 1221 nonusers were analyzed. The primary outcomes were an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m<sup>2</sup>, urinary albumin-to-creatinine ratio of ≥30 mg/g, and a composite outcome defined as new-onset CKD. <b>Results</b>: The multivariable Cox survival model showed that metformin users had significantly better renal outcomes, with a notably lower risk of sustained eGFR of <60 mL/min/1.73 m<sup>2</sup> (hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.56–0.90) and new CKD onset (HR, 0.78; 95% CI, 0.65–0.94). <b>Conclusions</b>: Metformin plays a key role in delaying renal events in individuals with type 2 diabetes mellitus and in those with initially normal renal function. |
| format | Article |
| id | doaj-art-fed3b32d659f40f09e8ca3ce1f1bde05 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-fed3b32d659f40f09e8ca3ce1f1bde052025-01-24T13:45:22ZengMDPI AGPharmaceuticals1424-82472025-01-011819510.3390/ph18010095Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes MellitusYu-Ling Lin0Sheng-Hsiang Lin1Hsi-Hao Wang2Wan-Chia Hsu3Shih-Yuan Hung4Yuan-Yow Chiou5Hung-Hsiang Liou6Min-Yu Chang7Li-Chun Ho8Ching-Fang Wu9Yi-Che Lee10Division of Nephrology, Department of Internal Medicine, Hsinchu Cathay General Hospital, Hsinchu 300, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanTaiwan School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 824, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanTaiwan School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 824, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDivision of Nephrology, Department of Internal Medicine, Hsin-Jen Hospital, New Taipei City 242, TaiwanTaiwan School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 824, TaiwanTaiwan School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 824, TaiwanTaiwan School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 824, TaiwanTaiwan School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan<b>Background</b>: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic kidney disease (CKD) in patients with type 2 diabetes mellitus with normal renal function remains unclear. Therefore, this study aimed to investigate whether metformin could prevent the development of new-onset CKD in such patients. <b>Methods</b>: This retrospective, observational, multicenter cohort study included 316,693 patients with type 2 diabetes mellitus. After matching using the inverse probability of treatment weighting, 9109 metformin users and 1221 nonusers were analyzed. The primary outcomes were an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m<sup>2</sup>, urinary albumin-to-creatinine ratio of ≥30 mg/g, and a composite outcome defined as new-onset CKD. <b>Results</b>: The multivariable Cox survival model showed that metformin users had significantly better renal outcomes, with a notably lower risk of sustained eGFR of <60 mL/min/1.73 m<sup>2</sup> (hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.56–0.90) and new CKD onset (HR, 0.78; 95% CI, 0.65–0.94). <b>Conclusions</b>: Metformin plays a key role in delaying renal events in individuals with type 2 diabetes mellitus and in those with initially normal renal function.https://www.mdpi.com/1424-8247/18/1/95chronic kidney diseasediabetes mellitusdiabetic kidney diseasekidneymetforminrenal |
| spellingShingle | Yu-Ling Lin Sheng-Hsiang Lin Hsi-Hao Wang Wan-Chia Hsu Shih-Yuan Hung Yuan-Yow Chiou Hung-Hsiang Liou Min-Yu Chang Li-Chun Ho Ching-Fang Wu Yi-Che Lee Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus Pharmaceuticals chronic kidney disease diabetes mellitus diabetic kidney disease kidney metformin renal |
| title | Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus |
| title_full | Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus |
| title_short | Role of Metformin in Preventing New-Onset Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus |
| title_sort | role of metformin in preventing new onset chronic kidney disease in patients with type 2 diabetes mellitus |
| topic | chronic kidney disease diabetes mellitus diabetic kidney disease kidney metformin renal |
| url | https://www.mdpi.com/1424-8247/18/1/95 |
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