Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection
The retinal fractal dimension (FD) is a measure of vasculature branching pattern complexity. FD has been considered as a potential biomarker for the detection of several diseases like diabetes and hypertension. However, conflicting findings were found in the reported literature regarding the associa...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/6259047 |
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| author | Fan Huang Behdad Dashtbozorg Jiong Zhang Erik Bekkers Samaneh Abbasi-Sureshjani Tos T. J. M. Berendschot Bart M. ter Haar Romeny |
| author_facet | Fan Huang Behdad Dashtbozorg Jiong Zhang Erik Bekkers Samaneh Abbasi-Sureshjani Tos T. J. M. Berendschot Bart M. ter Haar Romeny |
| author_sort | Fan Huang |
| collection | DOAJ |
| description | The retinal fractal dimension (FD) is a measure of vasculature branching pattern complexity. FD has been considered as a potential biomarker for the detection of several diseases like diabetes and hypertension. However, conflicting findings were found in the reported literature regarding the association between this biomarker and diseases. In this paper, we examine the stability of the FD measurement with respect to (1) different vessel annotations obtained from human observers, (2) automatic segmentation methods, (3) various regions of interest, (4) accuracy of vessel segmentation methods, and (5) different imaging modalities. Our results demonstrate that the relative errors for the measurement of FD are significant and FD varies considerably according to the image quality, modality, and the technique used for measuring it. Automated and semiautomated methods for the measurement of FD are not stable enough, which makes FD a deceptive biomarker in quantitative clinical applications. |
| format | Article |
| id | doaj-art-feb22055146b4627917ee766e1117967 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-feb22055146b4627917ee766e11179672025-02-03T01:28:49ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/62590476259047Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy DetectionFan Huang0Behdad Dashtbozorg1Jiong Zhang2Erik Bekkers3Samaneh Abbasi-Sureshjani4Tos T. J. M. Berendschot5Bart M. ter Haar Romeny6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NetherlandsUniversity Eye Clinic Maastricht, Maastricht, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NetherlandsThe retinal fractal dimension (FD) is a measure of vasculature branching pattern complexity. FD has been considered as a potential biomarker for the detection of several diseases like diabetes and hypertension. However, conflicting findings were found in the reported literature regarding the association between this biomarker and diseases. In this paper, we examine the stability of the FD measurement with respect to (1) different vessel annotations obtained from human observers, (2) automatic segmentation methods, (3) various regions of interest, (4) accuracy of vessel segmentation methods, and (5) different imaging modalities. Our results demonstrate that the relative errors for the measurement of FD are significant and FD varies considerably according to the image quality, modality, and the technique used for measuring it. Automated and semiautomated methods for the measurement of FD are not stable enough, which makes FD a deceptive biomarker in quantitative clinical applications.http://dx.doi.org/10.1155/2016/6259047 |
| spellingShingle | Fan Huang Behdad Dashtbozorg Jiong Zhang Erik Bekkers Samaneh Abbasi-Sureshjani Tos T. J. M. Berendschot Bart M. ter Haar Romeny Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection Journal of Ophthalmology |
| title | Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection |
| title_full | Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection |
| title_fullStr | Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection |
| title_full_unstemmed | Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection |
| title_short | Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection |
| title_sort | reliability of using retinal vascular fractal dimension as a biomarker in the diabetic retinopathy detection |
| url | http://dx.doi.org/10.1155/2016/6259047 |
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