Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior
Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/237260 |
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| author | Dario Coletti Emanuele Berardi Paola Aulino Eleonora Rossi Viviana Moresi Zhenlin Li Sergio Adamo |
| author_facet | Dario Coletti Emanuele Berardi Paola Aulino Eleonora Rossi Viviana Moresi Zhenlin Li Sergio Adamo |
| author_sort | Dario Coletti |
| collection | DOAJ |
| description | Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation to substrains of the same inbred mouse strain, that is, BALB/c mice. We found that only a minority of the population of one of these substrains, the BALB/c J, performs spontaneous physical activity. In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB/c ByJ and the BALB/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. This important amount of physical activity results in a minor muscle adaptation to endurance exercise over a three-week period; indeed, only a nonsignificant increase in NADH transferase+ fibers occurs in this time frame. |
| format | Article |
| id | doaj-art-feaaf2f2ba494830b5b6c73babd701ac |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-feaaf2f2ba494830b5b6c73babd701ac2025-02-03T01:31:46ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/237260237260Substrains of Inbred Mice Differ in Their Physical Activity as a BehaviorDario Coletti0Emanuele Berardi1Paola Aulino2Eleonora Rossi3Viviana Moresi4Zhenlin Li5Sergio Adamo6UR4 Aging, Stress, Inflammation, University Pierre et Marie Curie Paris 6, 7 Quai Saint Bernard, 75005 Paris, FranceLaboratory of Translational Cardiomyology, Department of Development and Regeneration, Katholieke Universiteit Leuven, 3000 Leuven, BelgiumUR4 Aging, Stress, Inflammation, University Pierre et Marie Curie Paris 6, 7 Quai Saint Bernard, 75005 Paris, FranceDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, ItalyDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, ItalyUR4 Aging, Stress, Inflammation, University Pierre et Marie Curie Paris 6, 7 Quai Saint Bernard, 75005 Paris, FranceDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, ItalyRecent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation to substrains of the same inbred mouse strain, that is, BALB/c mice. We found that only a minority of the population of one of these substrains, the BALB/c J, performs spontaneous physical activity. In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB/c ByJ and the BALB/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. This important amount of physical activity results in a minor muscle adaptation to endurance exercise over a three-week period; indeed, only a nonsignificant increase in NADH transferase+ fibers occurs in this time frame.http://dx.doi.org/10.1155/2013/237260 |
| spellingShingle | Dario Coletti Emanuele Berardi Paola Aulino Eleonora Rossi Viviana Moresi Zhenlin Li Sergio Adamo Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior The Scientific World Journal |
| title | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
| title_full | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
| title_fullStr | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
| title_full_unstemmed | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
| title_short | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
| title_sort | substrains of inbred mice differ in their physical activity as a behavior |
| url | http://dx.doi.org/10.1155/2013/237260 |
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