Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study
Background: Although evidence suggests that perfluoroalkyl and polyfluoroalkyl substances (PFASs) are positively correlated to several disease risks, no studies have proven if plasma PFASs are related to ovarian cancer survival. Objective: To explore the association between plasma PFASs and high-gra...
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Elsevier
2025-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001617 |
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| author | Wei-Yi Xing Fang-Hua Liu Dong-Dong Wang Jia-Ming Liu Wen-Rui Zheng Jia-Xin Liu Lang Wu Yue-Yang Zhao He-Li Xu Yi-Zi Li Yi-Fan Wei Dong-Hui Huang Xiao-Ying Li Song Gao Qi-Peng Ma Ting-Ting Gong Qi-Jun Wu |
| author_facet | Wei-Yi Xing Fang-Hua Liu Dong-Dong Wang Jia-Ming Liu Wen-Rui Zheng Jia-Xin Liu Lang Wu Yue-Yang Zhao He-Li Xu Yi-Zi Li Yi-Fan Wei Dong-Hui Huang Xiao-Ying Li Song Gao Qi-Peng Ma Ting-Ting Gong Qi-Jun Wu |
| author_sort | Wei-Yi Xing |
| collection | DOAJ |
| description | Background: Although evidence suggests that perfluoroalkyl and polyfluoroalkyl substances (PFASs) are positively correlated to several disease risks, no studies have proven if plasma PFASs are related to ovarian cancer survival. Objective: To explore the association between plasma PFASs and high-grade serous ovarian cancer (HGSOC) overall survival (OS) in the population who did not smoke. Methods: We conducted a nested case-control study within the Ovarian Cancer Follow-Up Study, matching 159 dead patients and 159 survival ones based on body mass index, sample date, and age at diagnosis. Nine plasma PFASs were extracted by solid phase extraction and measured using a liquid chromatography system coupled with tandem mass spectrometry. Baseline plasma concentrations of perfluorinated carboxylic acids (PFCAs) [perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroheptanoic acid (PFHpA)] and perfluorinated sulfonic acids (PFSAs) [perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS)] were calculated. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were calculated via conditional logistic regression models. To elucidate the combined effects, Bayesian kernel machine (BKMR), and regression quantile g-computation (QGC) models were utilized. Result: In full-adjusted model, significant differences were observed between HGSOC survival and perfluorobutane sulfonic acid, PFHpA, PFHxS, PFOS, PFCA, and PFSA. ORs and 95 %CIs were 2.74 (1.41–5.31), 1.97 (1.03–3.76), 2.13 (1.15–3.95), 2.28 (1.16–4.47), 3.74 (1.78–7.85), and 2.56 (1.31–5.01), respectively for the highest tertile compared with the lowest tertile. The QGC and BKMR models indicated that elevated concentrations of PFAS mixtures were associated with poor OS in HGSOC. Conclusions: Both individual and mixed plasma PFASs may relate to poor OS of HGSOC. Further research is necessary to establish causality, and it is recommended to reinforce environmental risk mitigation strategies to minimize PFAS exposure. |
| format | Article |
| id | doaj-art-fe9cdc47b1e54f1ba54e74a2a23aaf72 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-fe9cdc47b1e54f1ba54e74a2a23aaf722025-01-31T05:10:02ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117825Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control studyWei-Yi Xing0Fang-Hua Liu1Dong-Dong Wang2Jia-Ming Liu3Wen-Rui Zheng4Jia-Xin Liu5Lang Wu6Yue-Yang Zhao7He-Li Xu8Yi-Zi Li9Yi-Fan Wei10Dong-Hui Huang11Xiao-Ying Li12Song Gao13Qi-Peng Ma14Ting-Ting Gong15Qi-Jun Wu16Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaCancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USADepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China; Correspondence to: Department of Clinical Epidemiology, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding authors.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding authors.Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University), National Health Commission, Shenyang, China; Correspondence to: Department of Clinical Epidemiology, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Background: Although evidence suggests that perfluoroalkyl and polyfluoroalkyl substances (PFASs) are positively correlated to several disease risks, no studies have proven if plasma PFASs are related to ovarian cancer survival. Objective: To explore the association between plasma PFASs and high-grade serous ovarian cancer (HGSOC) overall survival (OS) in the population who did not smoke. Methods: We conducted a nested case-control study within the Ovarian Cancer Follow-Up Study, matching 159 dead patients and 159 survival ones based on body mass index, sample date, and age at diagnosis. Nine plasma PFASs were extracted by solid phase extraction and measured using a liquid chromatography system coupled with tandem mass spectrometry. Baseline plasma concentrations of perfluorinated carboxylic acids (PFCAs) [perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroheptanoic acid (PFHpA)] and perfluorinated sulfonic acids (PFSAs) [perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS)] were calculated. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were calculated via conditional logistic regression models. To elucidate the combined effects, Bayesian kernel machine (BKMR), and regression quantile g-computation (QGC) models were utilized. Result: In full-adjusted model, significant differences were observed between HGSOC survival and perfluorobutane sulfonic acid, PFHpA, PFHxS, PFOS, PFCA, and PFSA. ORs and 95 %CIs were 2.74 (1.41–5.31), 1.97 (1.03–3.76), 2.13 (1.15–3.95), 2.28 (1.16–4.47), 3.74 (1.78–7.85), and 2.56 (1.31–5.01), respectively for the highest tertile compared with the lowest tertile. The QGC and BKMR models indicated that elevated concentrations of PFAS mixtures were associated with poor OS in HGSOC. Conclusions: Both individual and mixed plasma PFASs may relate to poor OS of HGSOC. Further research is necessary to establish causality, and it is recommended to reinforce environmental risk mitigation strategies to minimize PFAS exposure.http://www.sciencedirect.com/science/article/pii/S0147651325001617Nested case-control studyOvarian cancerPerfluoroalkyl substancesPlasmaSurvival |
| spellingShingle | Wei-Yi Xing Fang-Hua Liu Dong-Dong Wang Jia-Ming Liu Wen-Rui Zheng Jia-Xin Liu Lang Wu Yue-Yang Zhao He-Li Xu Yi-Zi Li Yi-Fan Wei Dong-Hui Huang Xiao-Ying Li Song Gao Qi-Peng Ma Ting-Ting Gong Qi-Jun Wu Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study Ecotoxicology and Environmental Safety Nested case-control study Ovarian cancer Perfluoroalkyl substances Plasma Survival |
| title | Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study |
| title_full | Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study |
| title_fullStr | Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study |
| title_full_unstemmed | Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study |
| title_short | Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study |
| title_sort | association between plasma perfluoroalkyl substances and high grade serous ovarian cancer overall survival a nested case control study |
| topic | Nested case-control study Ovarian cancer Perfluoroalkyl substances Plasma Survival |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001617 |
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