Genomic Profiling of Liver Cancer
Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the cancer genome, it is very challenging to find...
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| Format: | Article |
| Language: | English |
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BioMed Central
2013-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-180.pdf |
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| _version_ | 1832570112042860544 |
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| author | Ju-Seog Lee |
| author_facet | Ju-Seog Lee |
| author_sort | Ju-Seog Lee |
| collection | DOAJ |
| description | Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the cancer genome, it is very challenging to find and test candidate genes driving tumor development and progression. Systematic studies of the liver cancer genome have become available in recent years. These studies have uncovered new potential driver genes, including those not previously known to be involved in the development of liver cancer. Novel approaches combining multiple datasets from patient tissues have created an unparalleled opportunity to uncover potential new therapeutic targets and prognostic/predictive biomarkers for personalized therapy that can improve clinical outcomes of the patients with liver cancer. |
| format | Article |
| id | doaj-art-fe8173d4afbc4e91be7064a25529f86e |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-fe8173d4afbc4e91be7064a25529f86e2025-02-02T17:14:44ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-12-0111418018510.5808/GI.2013.11.4.18057Genomic Profiling of Liver CancerJu-Seog Lee0Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the cancer genome, it is very challenging to find and test candidate genes driving tumor development and progression. Systematic studies of the liver cancer genome have become available in recent years. These studies have uncovered new potential driver genes, including those not previously known to be involved in the development of liver cancer. Novel approaches combining multiple datasets from patient tissues have created an unparalleled opportunity to uncover potential new therapeutic targets and prognostic/predictive biomarkers for personalized therapy that can improve clinical outcomes of the patients with liver cancer.http://genominfo.org/upload/pdf/gni-11-180.pdfgene expression profilingliver neoplasmsoligonucleotide array sequence analysis |
| spellingShingle | Ju-Seog Lee Genomic Profiling of Liver Cancer Genomics & Informatics gene expression profiling liver neoplasms oligonucleotide array sequence analysis |
| title | Genomic Profiling of Liver Cancer |
| title_full | Genomic Profiling of Liver Cancer |
| title_fullStr | Genomic Profiling of Liver Cancer |
| title_full_unstemmed | Genomic Profiling of Liver Cancer |
| title_short | Genomic Profiling of Liver Cancer |
| title_sort | genomic profiling of liver cancer |
| topic | gene expression profiling liver neoplasms oligonucleotide array sequence analysis |
| url | http://genominfo.org/upload/pdf/gni-11-180.pdf |
| work_keys_str_mv | AT juseoglee genomicprofilingoflivercancer |