Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye
Background: Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S. pyogenes strains responsible for infections in Türkiye and their susceptibility to beta-lactam and macrolide antibiotics. Methods: We determined the mini...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034124003678 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592831737233408 |
|---|---|
| author | Nihan Ünübol Nese Caglayan Sinan Cebeci Yeşim Beşli Banu Sancak Neval Yurttutan Uyar Siavosh Salmanzadeh Ahrabi Masoud Alebouyeh Tanıl Kocagöz |
| author_facet | Nihan Ünübol Nese Caglayan Sinan Cebeci Yeşim Beşli Banu Sancak Neval Yurttutan Uyar Siavosh Salmanzadeh Ahrabi Masoud Alebouyeh Tanıl Kocagöz |
| author_sort | Nihan Ünübol |
| collection | DOAJ |
| description | Background: Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S. pyogenes strains responsible for infections in Türkiye and their susceptibility to beta-lactam and macrolide antibiotics. Methods: We determined the minimum inhibitory concentration using the penicillin gradient test and performed emm typing and DNA fingerprinting via pulsed-field gel electrophoresis (PFGE) to analyze the clonal spread of 92 S. pyogenes strains isolated from two hospitals in Türkiye between 2020 and 2022. Results: Our findings revealed the predominant S. pyogenes strains causing infections in the population and provided insights into the epidemiological relatedness of these drug-resistant strains. This study also evaluated the correlation between emm typing and PFGE in tracking S. pyogenes epidemiology. In this study, the current resistance patterns of S. pyogenes strains in Türkiye identified erythromycin resistance in a few strains, but no resistance to penicillin was detected. Conclusions: This study revealed that emm types 1, 12 and 89 as S. pyogenes strain genotypes were responsible for epidemic infections in Türkiye. PFGE genotyping and emm typing were found to provide better phylogenetic classification in the investigation of S. pyogenes epidemiology. |
| format | Article |
| id | doaj-art-fe804c9054154d5da53fde3ac714bb9d |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-fe804c9054154d5da53fde3ac714bb9d2025-01-21T04:12:57ZengElsevierJournal of Infection and Public Health1876-03412025-02-01182102633Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in TürkiyeNihan Ünübol0Nese Caglayan1Sinan Cebeci2Yeşim Beşli3Banu Sancak4Neval Yurttutan Uyar5Siavosh Salmanzadeh Ahrabi6Masoud Alebouyeh7Tanıl Kocagöz8Department of Medical Microbiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Medical Laboratory Technician Program, Vocational School of Health Services, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Corresponding authors at: Department of Medical Microbiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyDepartment of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyDepartment of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyAmerican Hospital, Istanbul, TurkeyDepartment of Medical Microbiology, School of Medicine, Hacettepe University, Ankara, TurkeyMedical Laboratory Technician Program, Vocational School of Health Services, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Acibadem Labmed Clinical Laboratory, Istanbul, TurkeyDepartment of Microbiology, Alzahra University, Tehran, IranPediatric Infections Research Center, Reserch Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Microbiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Corresponding authors at: Department of Medical Microbiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyBackground: Drug-resistant Group A beta-hemolytic streptococci remain significant infectious agents globally. This study investigated the major S. pyogenes strains responsible for infections in Türkiye and their susceptibility to beta-lactam and macrolide antibiotics. Methods: We determined the minimum inhibitory concentration using the penicillin gradient test and performed emm typing and DNA fingerprinting via pulsed-field gel electrophoresis (PFGE) to analyze the clonal spread of 92 S. pyogenes strains isolated from two hospitals in Türkiye between 2020 and 2022. Results: Our findings revealed the predominant S. pyogenes strains causing infections in the population and provided insights into the epidemiological relatedness of these drug-resistant strains. This study also evaluated the correlation between emm typing and PFGE in tracking S. pyogenes epidemiology. In this study, the current resistance patterns of S. pyogenes strains in Türkiye identified erythromycin resistance in a few strains, but no resistance to penicillin was detected. Conclusions: This study revealed that emm types 1, 12 and 89 as S. pyogenes strain genotypes were responsible for epidemic infections in Türkiye. PFGE genotyping and emm typing were found to provide better phylogenetic classification in the investigation of S. pyogenes epidemiology.http://www.sciencedirect.com/science/article/pii/S1876034124003678Group A StreptococciDrug resistanceBeta-lactamMacrolide, PFGE, emm typing |
| spellingShingle | Nihan Ünübol Nese Caglayan Sinan Cebeci Yeşim Beşli Banu Sancak Neval Yurttutan Uyar Siavosh Salmanzadeh Ahrabi Masoud Alebouyeh Tanıl Kocagöz Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye Journal of Infection and Public Health Group A Streptococci Drug resistance Beta-lactam Macrolide, PFGE, emm typing |
| title | Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye |
| title_full | Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye |
| title_fullStr | Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye |
| title_full_unstemmed | Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye |
| title_short | Antimicrobial resistance and epidemiological patterns of Streptococcus pyogenes in Türkiye |
| title_sort | antimicrobial resistance and epidemiological patterns of streptococcus pyogenes in turkiye |
| topic | Group A Streptococci Drug resistance Beta-lactam Macrolide, PFGE, emm typing |
| url | http://www.sciencedirect.com/science/article/pii/S1876034124003678 |
| work_keys_str_mv | AT nihanunubol antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT nesecaglayan antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT sinancebeci antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT yesimbesli antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT banusancak antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT nevalyurttutanuyar antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT siavoshsalmanzadehahrabi antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT masoudalebouyeh antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye AT tanılkocagoz antimicrobialresistanceandepidemiologicalpatternsofstreptococcuspyogenesinturkiye |