The Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins Protects Against Microglia-Mediated Neuronal Loss In Vitro

The Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins Protects Against Microglia-Mediated Neuronal Loss In Vitro

Neuroinflammation is a key feature of all neurodegenerative disorders, including Alzheimer’s disease, and is tightly regulated by epigenetic mechanisms. Among them, bromodomain and extraterminal domain (BET) proteins play a crucial role by recognizing acetylated histones and acting as transcriptiona...

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Bibliographic Details
Main Authors: Marta Matuszewska, Anna Wilkaniec, Magdalena Cieślik, Marcin Strawski, Grzegorz A. Czapski
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomolecules
Subjects:
neuroinflammation
bromodomain and extraterminal domain proteins
neuroprotection
Alzheimer’s disease
microglia
Online Access:https://www.mdpi.com/2218-273X/15/4/528
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