Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
We presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complet...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/1992541 |
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| author | Florence M. F. Cheung Timothy Y. C. So Tony H. T. Sung Ying-Lee Lam |
| author_facet | Florence M. F. Cheung Timothy Y. C. So Tony H. T. Sung Ying-Lee Lam |
| author_sort | Florence M. F. Cheung |
| collection | DOAJ |
| description | We presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complete curettage specimen with relevant immunohistochemistry and molecular tests made the final diagnosis of DTSGCT possible. The biomolecular mechanism for the masquerading phenomenon was explained by CSF1 overexpression in the neoplastic cells attracting migration and proliferation of CSF1R-positive Langerhans cells. |
| format | Article |
| id | doaj-art-fe6cef9f9e804ccc97f5cab27594f2c9 |
| institution | Kabale University |
| issn | 1687-9635 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-fe6cef9f9e804ccc97f5cab27594f2c92025-02-03T01:19:58ZengWileyCase Reports in Medicine1687-96352022-01-01202210.1155/2022/1992541Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell HistiocytosisFlorence M. F. Cheung0Timothy Y. C. So1Tony H. T. Sung2Ying-Lee Lam3Department of Clinical PathologyMusculoskeletal Tumour CentreRadiology DepartmentDepartment of Orthopaedics and TraumatologyWe presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complete curettage specimen with relevant immunohistochemistry and molecular tests made the final diagnosis of DTSGCT possible. The biomolecular mechanism for the masquerading phenomenon was explained by CSF1 overexpression in the neoplastic cells attracting migration and proliferation of CSF1R-positive Langerhans cells.http://dx.doi.org/10.1155/2022/1992541 |
| spellingShingle | Florence M. F. Cheung Timothy Y. C. So Tony H. T. Sung Ying-Lee Lam Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis Case Reports in Medicine |
| title | Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis |
| title_full | Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis |
| title_fullStr | Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis |
| title_full_unstemmed | Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis |
| title_short | Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis |
| title_sort | diffuse type tenosynovial giant cell tumour involving bone masquerading as langerhans cell histiocytosis |
| url | http://dx.doi.org/10.1155/2022/1992541 |
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