Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions

Summary: ATP13A2 is an endolysosomal polyamine transporter mutated in several neurodegenerative conditions involving lysosomal defects, including Parkinson’s disease (PD). While polyamines are polybasic and polycationic molecules that play pleiotropic cellular roles, their specific impact on lysosom...

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Bibliographic Details
Main Authors:	Madhuja Samaddar, Gabriel A. Fitzgerald, Ann Hong Nguyen, Sonnet S. Davis, Shourya Jain, Jian Guo, Nicholas E. Propson, Bettina van Lengerich, Yajuan Shi, Srijana Balasundar, Lionel Rougé, Jamal Alkabsh, Anil Rana, Julie Yi, Marcus Y. Chin, Isabel A. Becerra, Annie Arguello, Brian M. Fox, Todd Logan, Jung H. Suh, Anastasia G. Henry, Gilbert Di Paolo
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Series:	Cell Reports
Subjects:	CP: Neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124725009507
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Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions

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