Ion Channel Regulation in Caveolae and Its Pathological Implications
Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation. These structures are composed of the caveolin protein family and are enriched in cholesterol and sphingolipids, creating a uniqu...
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MDPI AG
2025-04-01
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| author | Jianyi Huo Liangzhu Mo Xiaojing Lv Yun Du Huaqian Yang |
| author_facet | Jianyi Huo Liangzhu Mo Xiaojing Lv Yun Du Huaqian Yang |
| author_sort | Jianyi Huo |
| collection | DOAJ |
| description | Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation. These structures are composed of the caveolin protein family and are enriched in cholesterol and sphingolipids, creating a unique lipid microdomain. Caveolae contribute to the functional regulation of various ion channels through both physical interactions and involvement in complex signaling networks. Ion channels localized within caveolae are involved in critical cellular processes such as the generation and propagation of action potentials, cellular responses to mechanical forces, and regulation of metabolism. Dysregulation of caveolae function has been linked to the development of various diseases, including cardiovascular disorders, neurodegenerative diseases, metabolic syndrome, and cancer. This review summarizes the ion channel function and regulation in caveolae, and their pathological implications, offering new insights into their potential as therapeutic targets for ion channel-related diseases. |
| format | Article |
| id | doaj-art-fe6a2340a6fc4c20be4bbb3d7fe7d13b |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-fe6a2340a6fc4c20be4bbb3d7fe7d13b2025-08-20T02:24:47ZengMDPI AGCells2073-44092025-04-0114963110.3390/cells14090631Ion Channel Regulation in Caveolae and Its Pathological ImplicationsJianyi Huo0Liangzhu Mo1Xiaojing Lv2Yun Du3Huaqian Yang4Department of Cardiology, The Fourth Affiliated Hospital, Cyrus Tang Medical Institute, Medical College, Soochow University, Suzhou 215028, ChinaDepartment of Cardiology, The Fourth Affiliated Hospital, Cyrus Tang Medical Institute, Medical College, Soochow University, Suzhou 215028, ChinaDepartment of Cardiology, The Fourth Affiliated Hospital, Cyrus Tang Medical Institute, Medical College, Soochow University, Suzhou 215028, ChinaDepartment of Cardiology, The Fourth Affiliated Hospital, Cyrus Tang Medical Institute, Medical College, Soochow University, Suzhou 215028, ChinaDepartment of Cardiology, The Fourth Affiliated Hospital, Cyrus Tang Medical Institute, Medical College, Soochow University, Suzhou 215028, ChinaCaveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation. These structures are composed of the caveolin protein family and are enriched in cholesterol and sphingolipids, creating a unique lipid microdomain. Caveolae contribute to the functional regulation of various ion channels through both physical interactions and involvement in complex signaling networks. Ion channels localized within caveolae are involved in critical cellular processes such as the generation and propagation of action potentials, cellular responses to mechanical forces, and regulation of metabolism. Dysregulation of caveolae function has been linked to the development of various diseases, including cardiovascular disorders, neurodegenerative diseases, metabolic syndrome, and cancer. This review summarizes the ion channel function and regulation in caveolae, and their pathological implications, offering new insights into their potential as therapeutic targets for ion channel-related diseases.https://www.mdpi.com/2073-4409/14/9/631caveolaeion channelscaveolinmechanosensation |
| spellingShingle | Jianyi Huo Liangzhu Mo Xiaojing Lv Yun Du Huaqian Yang Ion Channel Regulation in Caveolae and Its Pathological Implications Cells caveolae ion channels caveolin mechanosensation |
| title | Ion Channel Regulation in Caveolae and Its Pathological Implications |
| title_full | Ion Channel Regulation in Caveolae and Its Pathological Implications |
| title_fullStr | Ion Channel Regulation in Caveolae and Its Pathological Implications |
| title_full_unstemmed | Ion Channel Regulation in Caveolae and Its Pathological Implications |
| title_short | Ion Channel Regulation in Caveolae and Its Pathological Implications |
| title_sort | ion channel regulation in caveolae and its pathological implications |
| topic | caveolae ion channels caveolin mechanosensation |
| url | https://www.mdpi.com/2073-4409/14/9/631 |
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