Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism
This study aimed to investigate the protective effects of fleshes from two Actinidia chinensis (ACF), pericarps from two A. chinensis (ACP), and fleshes with pericarps from two A. chinensis (ACFP) on high fructose (HF)-instigated dyslipidemia, hepatic steatosis, oxidative stress, insulin resistance,...
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| Format: | Article |
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000393 |
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| author | Aamina Alim Ting Li Tanzeela Nisar Zeshan Ali Daoyuan Ren Yueyue Liu Xingbin Yang |
| author_facet | Aamina Alim Ting Li Tanzeela Nisar Zeshan Ali Daoyuan Ren Yueyue Liu Xingbin Yang |
| author_sort | Aamina Alim |
| collection | DOAJ |
| description | This study aimed to investigate the protective effects of fleshes from two Actinidia chinensis (ACF), pericarps from two A. chinensis (ACP), and fleshes with pericarps from two A. chinensis (ACFP) on high fructose (HF)-instigated dyslipidemia, hepatic steatosis, oxidative stress, insulin resistance, and fatty acid metabolism disorders in rats. In general, the above abnormalities were improved after 10 weeks intervention of ACF, ACP, and ACFP. Especially, ACFP considerably ameliorated HF-induced abnormal changes in body weight gain, serum TC, TG, LDL-C and HDL-C levels, as well as serum and hepatic SFAs, MUFAs and PUFAs contents. ACFP also alleviated HF-induced hyperglycemia and hyperinsulinemia, stabilized HF-caused increase in hepatic MDA and serum ALT, AST levels, and restored HF-declined hepatic T-SOD and GSH-Px activities. Besides, histopathology of the liver further endorsed the protective effects of ACFP on hepatocellular injury. Moreover, ACFP increased HF-dropped acetic, propionic and butyric acid levels. Overall, ACFP employs more efficacious protective effects against HF-induced metabolic disorders and liver damage than ACF and ACP. This study delivers a scientific foundation for developing kiwifruit (counting peel)-based dietary supplements for those with glucolipid-metabolic disorders and liver damage. |
| format | Article |
| id | doaj-art-fe6419f366924a7ea13a9f2700631eae |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-fe6419f366924a7ea13a9f2700631eae2025-02-03T00:27:37ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112518721884Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolismAamina Alim0Ting Li1Tanzeela Nisar2Zeshan Ali3Daoyuan Ren4Yueyue Liu5Xingbin Yang6Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, ChinaShaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China; Corresponding authors at: College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Lahore 54000, PakistanDepartment of Life sciences, Barani Institution, Sahiwal 57000, PakistanShaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, ChinaShaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, ChinaShaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China; Corresponding authors at: College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.This study aimed to investigate the protective effects of fleshes from two Actinidia chinensis (ACF), pericarps from two A. chinensis (ACP), and fleshes with pericarps from two A. chinensis (ACFP) on high fructose (HF)-instigated dyslipidemia, hepatic steatosis, oxidative stress, insulin resistance, and fatty acid metabolism disorders in rats. In general, the above abnormalities were improved after 10 weeks intervention of ACF, ACP, and ACFP. Especially, ACFP considerably ameliorated HF-induced abnormal changes in body weight gain, serum TC, TG, LDL-C and HDL-C levels, as well as serum and hepatic SFAs, MUFAs and PUFAs contents. ACFP also alleviated HF-induced hyperglycemia and hyperinsulinemia, stabilized HF-caused increase in hepatic MDA and serum ALT, AST levels, and restored HF-declined hepatic T-SOD and GSH-Px activities. Besides, histopathology of the liver further endorsed the protective effects of ACFP on hepatocellular injury. Moreover, ACFP increased HF-dropped acetic, propionic and butyric acid levels. Overall, ACFP employs more efficacious protective effects against HF-induced metabolic disorders and liver damage than ACF and ACP. This study delivers a scientific foundation for developing kiwifruit (counting peel)-based dietary supplements for those with glucolipid-metabolic disorders and liver damage.http://www.sciencedirect.com/science/article/pii/S2213453023000393Actinidia chinensis peelLipid homeostasisOxidative stressInsulin resistanceHepatocellular injuryFatty acid metabolism |
| spellingShingle | Aamina Alim Ting Li Tanzeela Nisar Zeshan Ali Daoyuan Ren Yueyue Liu Xingbin Yang Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism Food Science and Human Wellness Actinidia chinensis peel Lipid homeostasis Oxidative stress Insulin resistance Hepatocellular injury Fatty acid metabolism |
| title | Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism |
| title_full | Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism |
| title_fullStr | Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism |
| title_full_unstemmed | Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism |
| title_short | Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association with improvement of fatty acids metabolism |
| title_sort | polyphenols and pectin enriched golden kiwifruit actinidia chinensis alleviates high fructose induced glucolipid disorders and hepatic oxidative damage in rats in association with improvement of fatty acids metabolism |
| topic | Actinidia chinensis peel Lipid homeostasis Oxidative stress Insulin resistance Hepatocellular injury Fatty acid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000393 |
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