The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process
Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0012 |
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| author | Poursina Narges Vatanara Alireza Rouini Mohammad Reza Gilani Kambiz Najafabadi Abdolhossein Rouholamini |
| author_facet | Poursina Narges Vatanara Alireza Rouini Mohammad Reza Gilani Kambiz Najafabadi Abdolhossein Rouholamini |
| author_sort | Poursina Narges |
| collection | DOAJ |
| description | Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content). |
| format | Article |
| id | doaj-art-fe5c363dafc84ca49478952c5eeaea21 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-fe5c363dafc84ca49478952c5eeaea212025-02-02T08:32:25ZengSciendoActa Pharmaceutica1846-95582016-06-0166220721810.1515/acph-2016-0012acph-2016-0012The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying processPoursina Narges0Vatanara Alireza1Rouini Mohammad Reza2Gilani Kambiz3Najafabadi Abdolhossein Rouholamini4Department of Pharmaceutics Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranSpray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content).https://doi.org/10.1515/acph-2016-0012salmon calcitonininhalationspray freeze dryinghydroxypropyl-β-cyclodextrinfine particle fractionstability |
| spellingShingle | Poursina Narges Vatanara Alireza Rouini Mohammad Reza Gilani Kambiz Najafabadi Abdolhossein Rouholamini The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process Acta Pharmaceutica salmon calcitonin inhalation spray freeze drying hydroxypropyl-β-cyclodextrin fine particle fraction stability |
| title | The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process |
| title_full | The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process |
| title_fullStr | The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process |
| title_full_unstemmed | The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process |
| title_short | The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process |
| title_sort | effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process |
| topic | salmon calcitonin inhalation spray freeze drying hydroxypropyl-β-cyclodextrin fine particle fraction stability |
| url | https://doi.org/10.1515/acph-2016-0012 |
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