Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being pai...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/962383 |
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| _version_ | 1832545965889814528 |
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| author | Songyan Wang Bing Li Chunguang Li Wenpeng Cui Lining Miao |
| author_facet | Songyan Wang Bing Li Chunguang Li Wenpeng Cui Lining Miao |
| author_sort | Songyan Wang |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. In this review, we only focus on the potential renoprotective therapeutic agents which can specifically abolish CCN2 expression or nonspecifically inhibit CCN2 expression for retarding the development and progression of DN. |
| format | Article |
| id | doaj-art-fe5ae91e51f74389abb5f90e07a3cded |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fe5ae91e51f74389abb5f90e07a3cded2025-02-03T07:24:20ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/962383962383Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic NephropathySongyan Wang0Bing Li1Chunguang Li2Wenpeng Cui3Lining Miao4Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Jilin Province People’s Hospital, Changchun 130021, ChinaDepartment of Urology, The 2nd Hospital of Changchun, Changchun 130061, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDiabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. In this review, we only focus on the potential renoprotective therapeutic agents which can specifically abolish CCN2 expression or nonspecifically inhibit CCN2 expression for retarding the development and progression of DN.http://dx.doi.org/10.1155/2015/962383 |
| spellingShingle | Songyan Wang Bing Li Chunguang Li Wenpeng Cui Lining Miao Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy Journal of Diabetes Research |
| title | Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy |
| title_full | Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy |
| title_fullStr | Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy |
| title_full_unstemmed | Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy |
| title_short | Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy |
| title_sort | potential renoprotective agents through inhibiting ctgf ccn2 in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2015/962383 |
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