Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract
Abstract Information on mid-term outcomes of percutaneous pulmonary valve replacement (PPVR) with the Edwards Sapien (ES) valve in the native right ventricular outflow tract (RVOT) are limited. This study assesses mid-term outcomes in 76 patients who underwent PPVR between 2016 and 2022, comparing n...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82336-4 |
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| author | Yassin Belahnech Gerard Martí-Aguasca Laura Dos-Subirà Pedro Betrian-Blasco Bruno García del Blanco Maria Calvo-Barceló Eduard Ródenas-Alesina Antonia Pijuan-Domènech Ferran Gran Queralt Ferrer Gemma Giralt-García Berta Miranda Blanca Gordon Víctor González-Fernández José A. Barrabés Ferran Roses-Noguer Ignacio Ferreira-González |
| author_facet | Yassin Belahnech Gerard Martí-Aguasca Laura Dos-Subirà Pedro Betrian-Blasco Bruno García del Blanco Maria Calvo-Barceló Eduard Ródenas-Alesina Antonia Pijuan-Domènech Ferran Gran Queralt Ferrer Gemma Giralt-García Berta Miranda Blanca Gordon Víctor González-Fernández José A. Barrabés Ferran Roses-Noguer Ignacio Ferreira-González |
| author_sort | Yassin Belahnech |
| collection | DOAJ |
| description | Abstract Information on mid-term outcomes of percutaneous pulmonary valve replacement (PPVR) with the Edwards Sapien (ES) valve in the native right ventricular outflow tract (RVOT) are limited. This study assesses mid-term outcomes in 76 patients who underwent PPVR between 2016 and 2022, comparing native (40.8%) and non-native (59.2%) RVOTs. The primary endpoint was a composite of endocarditis, reinterventions, and cardiovascular death and secondary outcomes included prosthetic valve dysfunction (PVD), tricuspid regurgitation (TR), right ventricular ejection fraction (RVEF), and indexed ventricular volumes. The median patient age was 23.9 years. Pulmonary regurgitation was predominant in the native RVOT group (67.7%), while pulmonary stenosis or combined lesions were more common in the non-native group (90.9%). Procedural success was 98.7%. After a median follow-up of 3.3 years, there was no significant difference in freedom from the primary outcome between groups (87.1% native vs. 93.1% non-native, p = 0.875). Endocarditis and reinterventions occurred at 1.2 per 100 patient-years, and PVD at 3.19 per 100 patient-years, with no differences between groups. A 1-year reduction in ventricular volumes and TR was seen only in the non-native group, with no improvement in RVEF. Overall, PPVR with the ES valve demonstrates satisfactory mid-term outcomes in both native and non-native RVOTs. |
| format | Article |
| id | doaj-art-fe47a67aa7b9473cbd4445f80c37221f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-fe47a67aa7b9473cbd4445f80c37221f2025-02-02T12:21:56ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-024-82336-4Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tractYassin Belahnech0Gerard Martí-Aguasca1Laura Dos-Subirà2Pedro Betrian-Blasco3Bruno García del Blanco4Maria Calvo-Barceló5Eduard Ródenas-Alesina6Antonia Pijuan-Domènech7Ferran Gran8Queralt Ferrer9Gemma Giralt-García10Berta Miranda11Blanca Gordon12Víctor González-Fernández13José A. Barrabés14Ferran Roses-Noguer15Ignacio Ferreira-González16Cardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaEuropean Reference Network for Rare, Low-Prevalence, Or Complex Diseases of the Heart (ERN GUARD-Heart)Cardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaEuropean Reference Network for Rare, Low-Prevalence, Or Complex Diseases of the Heart (ERN GUARD-Heart)European Reference Network for Rare, Low-Prevalence, Or Complex Diseases of the Heart (ERN GUARD-Heart)European Reference Network for Rare, Low-Prevalence, Or Complex Diseases of the Heart (ERN GUARD-Heart)Cardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaCardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaEuropean Reference Network for Rare, Low-Prevalence, Or Complex Diseases of the Heart (ERN GUARD-Heart)Cardiology Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Universitat Autònoma de BarcelonaAbstract Information on mid-term outcomes of percutaneous pulmonary valve replacement (PPVR) with the Edwards Sapien (ES) valve in the native right ventricular outflow tract (RVOT) are limited. This study assesses mid-term outcomes in 76 patients who underwent PPVR between 2016 and 2022, comparing native (40.8%) and non-native (59.2%) RVOTs. The primary endpoint was a composite of endocarditis, reinterventions, and cardiovascular death and secondary outcomes included prosthetic valve dysfunction (PVD), tricuspid regurgitation (TR), right ventricular ejection fraction (RVEF), and indexed ventricular volumes. The median patient age was 23.9 years. Pulmonary regurgitation was predominant in the native RVOT group (67.7%), while pulmonary stenosis or combined lesions were more common in the non-native group (90.9%). Procedural success was 98.7%. After a median follow-up of 3.3 years, there was no significant difference in freedom from the primary outcome between groups (87.1% native vs. 93.1% non-native, p = 0.875). Endocarditis and reinterventions occurred at 1.2 per 100 patient-years, and PVD at 3.19 per 100 patient-years, with no differences between groups. A 1-year reduction in ventricular volumes and TR was seen only in the non-native group, with no improvement in RVEF. Overall, PPVR with the ES valve demonstrates satisfactory mid-term outcomes in both native and non-native RVOTs.https://doi.org/10.1038/s41598-024-82336-4Congenital heart diseasePulmonary valvePercutaneous pulmonary valve replacementEdwards Sapien |
| spellingShingle | Yassin Belahnech Gerard Martí-Aguasca Laura Dos-Subirà Pedro Betrian-Blasco Bruno García del Blanco Maria Calvo-Barceló Eduard Ródenas-Alesina Antonia Pijuan-Domènech Ferran Gran Queralt Ferrer Gemma Giralt-García Berta Miranda Blanca Gordon Víctor González-Fernández José A. Barrabés Ferran Roses-Noguer Ignacio Ferreira-González Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract Scientific Reports Congenital heart disease Pulmonary valve Percutaneous pulmonary valve replacement Edwards Sapien |
| title | Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract |
| title_full | Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract |
| title_fullStr | Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract |
| title_full_unstemmed | Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract |
| title_short | Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract |
| title_sort | mid term outcomes of percutaneous pulmonary valve replacement with edwards sapien bioprosthesis in native right ventricular outflow tract |
| topic | Congenital heart disease Pulmonary valve Percutaneous pulmonary valve replacement Edwards Sapien |
| url | https://doi.org/10.1038/s41598-024-82336-4 |
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