Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia
Immunological alterations, endothelial dysfunction, and insulin resistance characterize preeclampsia. Endothelial cells hold the key role in the pathogenesis of this disease. The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/7695648 |
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| author | Sirilaksana Kunjara Patricia McLean Laurens Rademacher Thomas W. Rademacher Fabiana Fascilla Stefano Bettocchi Marco Scioscia |
| author_facet | Sirilaksana Kunjara Patricia McLean Laurens Rademacher Thomas W. Rademacher Fabiana Fascilla Stefano Bettocchi Marco Scioscia |
| author_sort | Sirilaksana Kunjara |
| collection | DOAJ |
| description | Immunological alterations, endothelial dysfunction, and insulin resistance characterize preeclampsia. Endothelial cells hold the key role in the pathogenesis of this disease. The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell survival, proliferation, and metabolism. Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia. Intracellular action of these molecules is deeply affected by zinc, manganese, and calcium. To evaluate the pathophysiological significance, we present the response of the intracellular pathways of inositol phosphoglycans involved in cellular metabolism and propose a link with the disease. |
| format | Article |
| id | doaj-art-fe479704e8c646c3af3d69ec9c6f4c75 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fe479704e8c646c3af3d69ec9c6f4c752025-02-03T01:02:05ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/76956487695648Putative Key Role of Inositol Messengers in Endothelial Cells in PreeclampsiaSirilaksana Kunjara0Patricia McLean1Laurens Rademacher2Thomas W. Rademacher3Fabiana Fascilla4Stefano Bettocchi5Marco Scioscia6Division of Biosciences, Research Department of Cell and Developmental Biology, University College London, London, UKDivision of Biosciences, Research Department of Cell and Developmental Biology, University College London, London, UKEmergex Vaccines Ltd, Abingdon, Oxfordshire, UKDivision of Infection and Immunity, University College London, London, UKDepartment of Biomedical Sciences and Human Oncology (DIMO), II Unit of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, ItalyDepartment of Biomedical Sciences and Human Oncology (DIMO), II Unit of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, ItalyDepartment of Obstetrics and Gynecology, Sacro Cuore Don Calabria, Negrar, Verona, ItalyImmunological alterations, endothelial dysfunction, and insulin resistance characterize preeclampsia. Endothelial cells hold the key role in the pathogenesis of this disease. The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell survival, proliferation, and metabolism. Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia. Intracellular action of these molecules is deeply affected by zinc, manganese, and calcium. To evaluate the pathophysiological significance, we present the response of the intracellular pathways of inositol phosphoglycans involved in cellular metabolism and propose a link with the disease.http://dx.doi.org/10.1155/2016/7695648 |
| spellingShingle | Sirilaksana Kunjara Patricia McLean Laurens Rademacher Thomas W. Rademacher Fabiana Fascilla Stefano Bettocchi Marco Scioscia Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia International Journal of Endocrinology |
| title | Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia |
| title_full | Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia |
| title_fullStr | Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia |
| title_full_unstemmed | Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia |
| title_short | Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia |
| title_sort | putative key role of inositol messengers in endothelial cells in preeclampsia |
| url | http://dx.doi.org/10.1155/2016/7695648 |
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