Multimodal Imaging in Stem Cell Therapy for Retinal Disease
Stem cell therapy has emerged as a promising approach for treating various retinal diseases, particularly degenerative retinal diseases such as geographic atrophy in age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt disease. A wide variety of imaging techniques have be...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Photonics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6732/12/5/413 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849327207010271232 |
|---|---|
| author | Mi Zheng Yannis M. Paulus |
| author_facet | Mi Zheng Yannis M. Paulus |
| author_sort | Mi Zheng |
| collection | DOAJ |
| description | Stem cell therapy has emerged as a promising approach for treating various retinal diseases, particularly degenerative retinal diseases such as geographic atrophy in age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt disease. A wide variety of imaging techniques have been employed in both preclinical and clinical settings to assess the efficacy and safety of stem cell therapy for retinal diseases. These techniques can be classified into two categories: methods for imaging stem cells and those for the overall morphology and function of the retina. The techniques employed for stem cell imaging include optical imaging, magnetic resonance imaging (MRI), and radionuclide imaging. Additional imaging techniques include fundus photography, fluorescein angiography, and fundus autofluorescence. Each technique has its own advantages and disadvantages, and thus, the use of multimodal imaging can help to overcome the shortcomings and achieve a more comprehensive evaluation of stem cell therapy in retinal disease. This review discusses the characteristics of the main techniques and cell-labeling techniques applied in stem cell therapy, with a particular focus on the applications of multimodal imaging. Furthermore, this review discusses the challenges and prospects of multimodal imaging in stem cell therapy for retinal disease. |
| format | Article |
| id | doaj-art-fe3f3a4bdb8d4c8d82d75e7f52c3ea60 |
| institution | Kabale University |
| issn | 2304-6732 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj-art-fe3f3a4bdb8d4c8d82d75e7f52c3ea602025-08-20T03:47:57ZengMDPI AGPhotonics2304-67322025-04-0112541310.3390/photonics12050413Multimodal Imaging in Stem Cell Therapy for Retinal DiseaseMi Zheng0Yannis M. Paulus1Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USADepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USAStem cell therapy has emerged as a promising approach for treating various retinal diseases, particularly degenerative retinal diseases such as geographic atrophy in age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt disease. A wide variety of imaging techniques have been employed in both preclinical and clinical settings to assess the efficacy and safety of stem cell therapy for retinal diseases. These techniques can be classified into two categories: methods for imaging stem cells and those for the overall morphology and function of the retina. The techniques employed for stem cell imaging include optical imaging, magnetic resonance imaging (MRI), and radionuclide imaging. Additional imaging techniques include fundus photography, fluorescein angiography, and fundus autofluorescence. Each technique has its own advantages and disadvantages, and thus, the use of multimodal imaging can help to overcome the shortcomings and achieve a more comprehensive evaluation of stem cell therapy in retinal disease. This review discusses the characteristics of the main techniques and cell-labeling techniques applied in stem cell therapy, with a particular focus on the applications of multimodal imaging. Furthermore, this review discusses the challenges and prospects of multimodal imaging in stem cell therapy for retinal disease.https://www.mdpi.com/2304-6732/12/5/413multimodal imagingoptical imagingretinal imagingstem cell therapyretinal diseaseretinal degenerative disease |
| spellingShingle | Mi Zheng Yannis M. Paulus Multimodal Imaging in Stem Cell Therapy for Retinal Disease Photonics multimodal imaging optical imaging retinal imaging stem cell therapy retinal disease retinal degenerative disease |
| title | Multimodal Imaging in Stem Cell Therapy for Retinal Disease |
| title_full | Multimodal Imaging in Stem Cell Therapy for Retinal Disease |
| title_fullStr | Multimodal Imaging in Stem Cell Therapy for Retinal Disease |
| title_full_unstemmed | Multimodal Imaging in Stem Cell Therapy for Retinal Disease |
| title_short | Multimodal Imaging in Stem Cell Therapy for Retinal Disease |
| title_sort | multimodal imaging in stem cell therapy for retinal disease |
| topic | multimodal imaging optical imaging retinal imaging stem cell therapy retinal disease retinal degenerative disease |
| url | https://www.mdpi.com/2304-6732/12/5/413 |
| work_keys_str_mv | AT mizheng multimodalimaginginstemcelltherapyforretinaldisease AT yannismpaulus multimodalimaginginstemcelltherapyforretinaldisease |